114399-88-1

Basic information

• Product Name: α,α-diphenyl-1-(phenylmethyl)-4-piperidinemethanol
• Synonyms: α,α-diphenyl-1-(phenylmethyl)-4-piperidinemethanol
• CAS NO: 114399-88-1
• Molecular Weight: 357.495
• Mol File: 114399-88-1.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: α,α-diphenyl-1-(phenylmethyl)-4-piperidinemethanol(CAS DataBase Reference)
• NIST Chemistry Reference: α,α-diphenyl-1-(phenylmethyl)-4-piperidinemethanol(114399-88-1)
• EPA Substance Registry System: α,α-diphenyl-1-(phenylmethyl)-4-piperidinemethanol(114399-88-1)

Safety Data

• Hazardous Substances Data: 114399-88-1(Hazardous Substances Data)

Upstream product

• 100-39-0 benzyl bromide 
• 1126-09-6 4-carbethoxypiperidine 
• 24228-40-8 N-benzyl isonipecotic acid ethyl ester 
• 37586-22-4 4-benzoylpiperidine 
• 100-58-3 phenylmagnesium bromide 
• 108-86-1 bromobenzene 

Downstream Products

• 112818-77-6 ethyl 4-(hydroxydiphenylmethyl)piperidine-1-carboxylate 
• 115-46-8 C₁₈H₂₁NO 
• 117022-92-1 1-(3-Methoxy-4-{3-[4-(methoxy-diphenyl-methyl)-piperidin-1-yl]-propoxy}-phenyl)-ethanone; compound with oxalic acid 
• 60284-76-6 1-[4-[3-[4-(Diphenylhydroxymethyl)-1-piperidinyl]propoxy]-3-methoxyphenyl]ethanone oxalate 
• 117023-68-4 4-[3-[4-[Hydroxy(diphenyl)methyl]-1-piperidinyl]propoxy]benzoic acid methyl ester 
• 117023-22-0 (1-(3-phenoxypropyl)piperidin-4-yl)diphenylmethanol 
• 117022-66-9 4-(diphenylmethoxymethyl)piperidine 
• 117022-65-8 4-(methoxydiphenylmethyl)-1-(phenylmethyl)piperidine 

Relevant articles and documents

Resin-immobilised benzyl and aryl vinyl sulfones: New versatile traceless linkers for solid-phase organic synthesis

New polystyrene-based resins containing benzyl and aryl vinyl sulfone groups are described. The vinyl sulfone group reacts efficiently with 2°amines, via conjugate addition, and the resin-bound 3°amines products can be quaternised through alkylation. Subsequent deamination to give 3°amines and the regenerated vinyl sulfone occurs in moderate to good yield. Both systems can be recycled and show moderate stability to acids and high stability to nucleophiles including Grignard reagents.

4-[diaryl)hydroxymethyl]-1-piperidinealkylcarboxylic acids, salts and esters useful in the treatment of allergic disorders

Novel compounds useful in the treatment of allergic disorders and having the formula: STR1 where Ar and Ar1 are pyridinyl, phenyl, or substituted phenyl and where Y is --OH,--O? M≈ m,--O--loweralkyl, --O--Aryl, or NR1 R2 (R1, R2 =H, loweralkyl, aryl) are herein disclosed.

4-[(α,α-diaryl)-hydroxymethyl]-1-piperidinylalkyl-cyclic carbamate derivatives as allergic response inhibitors

4-[(α,α-Diaryl)-hydroxymethyl]-1-piperidinylalkylcyclic carbamate derivatives having the formula: STR1 wherein; R is hydrogen, loweralkyl, cycloalkyl, phenyl and substituted phenyl; Ar and Ar1 are phenyl, substituted phenyl or pyridinyl; alk is a straight or branched hydrocarbon chain; R1 is loweralkyl substituted for hydrogen on a ring carbon. The compounds are useful antihistamines and in controlling allergic response.