1144113-16-5 Usage
Description
Tr-PEG9 is a PEG linker with a trityl protecting group and a terminal hydroxyl group. It is designed to increase the water solubility of compounds in aqueous media due to its hydrophilic PEG chain. The trityl protecting group is suitable for primary alcohols and can be removed under mild acidic conditions, allowing for further derivatization of the compound.
Uses
Used in Pharmaceutical Industry:
Tr-PEG9 is used as a solubility enhancer for hydrophobic drugs, improving their water solubility and bioavailability. This allows for better absorption and distribution of the drug within the body, leading to enhanced therapeutic effects.
Used in Chemical Synthesis:
Tr-PEG9 is used as a versatile building block in the synthesis of various chemical compounds. The terminal hydroxyl group allows for further derivatization, enabling the attachment of functional groups or other molecules to the PEG chain. This can be useful in the development of new drugs, bioconjugates, or other specialized chemical products.
Used in Drug Delivery Systems:
Tr-PEG9 is used as a component in drug delivery systems, such as nanoparticles or hydrogels, to improve the stability, solubility, and controlled release of therapeutic agents. The hydrophilic PEG chain can help in the formation of these systems and provide a protective environment for the encapsulated drugs, enhancing their efficacy and reducing side effects.
Used in Bioconjugation:
Tr-PEG9 is used as a linker in bioconjugation processes, where it can be used to attach biologically active molecules, such as peptides, proteins, or nucleic acids, to other molecules or surfaces. The trityl protecting group allows for selective deprotection and subsequent attachment of the target molecule, while the PEG chain can provide steric stabilization and reduce immunogenicity or non-specific interactions.
Check Digit Verification of cas no
The CAS Registry Mumber 1144113-16-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,4,4,1,1 and 3 respectively; the second part has 2 digits, 1 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1144113-16:
(9*1)+(8*1)+(7*4)+(6*4)+(5*1)+(4*1)+(3*3)+(2*1)+(1*6)=95
95 % 10 = 5
So 1144113-16-5 is a valid CAS Registry Number.
1144113-16-5Relevant articles and documents
Ligand-Phospholipid Conjugation: A Versatile Strategy for Developing Long-Acting Ligands That Bind to Membrane Proteins by Restricting the Subcellular Localization of the Ligand
Kawamura, Shuhei,Ito, Yoshihiko,Hirokawa, Takatsugu,Hikiyama, Eriko,Yamada, Shizuo,Shuto, Satoshi
, p. 4020 - 4029 (2018/05/07)
We hypothesized that if drug localization can be restricted to a particular subcellular domain where their target proteins reside, the drugs could bind to their target proteins without being metabolized and/or excreted, which would significantly extend the half-life of the corresponding drug-target complex. Thus, we designed ligand-phospholipid conjugates in which the ligand is conjugated with a phospholipid through a polyethylene glycol linker to restrict the subcellular localization of the ligand in the vicinity of the lipid bilayer. Here, we present the design, synthesis, pharmacological activity, and binding mode analysis of ligand-phospholipid conjugates with muscarinic acetylcholine receptors as the target proteins. These results demonstrate that ligand-phospholipid conjugation can be a versatile strategy for developing long-acting ligands that bind to membrane proteins in drug discovery.
High-purity discrete PEG-oligomer crystals allow structural insight
French, Alister C.,Thompson, Amber L.,Davis, Benjamin G.
supporting information; experimental part, p. 1248 - 1252 (2009/06/30)
To great (monodisperse) lengths: An improved synthesis of purer ethylene glycol (EG) oligomers allows access to 16- and 32-mers pure enough for multiple incorporation, and also to the longest (48-mer) discrete EG oligomer yet reported. The high purity enables the first crystallizations and hence the first glimpses of secondary 310-helical PEG structures.
