114438-33-4 Usage
Description
Sulfamethoxazole hydroxylamine is a sulfonamide compound derived from sulfamethoxazole, characterized by a 4-hydroxylaminophenyl group attached to the sulfur atom and a 1,2-oxazol-3-yl group attached to the nitrogen atom. It is an off-white to pale yellow solid and is known for its pharmaceutical applications.
Uses
Used in Pharmaceutical Industry:
Sulfamethoxazole hydroxylamine is used as an intermediate in the synthesis of various pharmaceutical compounds for its potential therapeutic properties.
Used in Research and Development:
In the field of research and development, sulfamethoxazole hydroxylamine serves as a valuable compound for studying the structure-activity relationships of sulfonamide drugs and for developing new drugs with improved efficacy and safety profiles.
Used in Drug Metabolism Studies:
As a metabolite of sulfamethoxazole, it is used in drug metabolism studies to understand the biotransformation processes and pharmacokinetics of the parent drug, which can help in optimizing drug dosages and minimizing side effects.
Used in Quality Control and Standardization:
Sulfamethoxazole hydroxylamine is utilized as a reference compound in the quality control and standardization of sulfonamide drugs, ensuring their purity, potency, and consistency across different batches and manufacturers.
Check Digit Verification of cas no
The CAS Registry Mumber 114438-33-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,4,4,3 and 8 respectively; the second part has 2 digits, 3 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 114438-33:
(8*1)+(7*1)+(6*4)+(5*4)+(4*3)+(3*8)+(2*3)+(1*3)=104
104 % 10 = 4
So 114438-33-4 is a valid CAS Registry Number.
InChI:InChI=1/C10H11N3O4S/c1-7-6-10(12-17-7)13-18(15,16)9-4-2-8(11-14)3-5-9/h2-6,11,14H,1H3,(H,12,13)
114438-33-4Relevant articles and documents
Synthesis and reactions of nitroso sulphamethoxazole with biological nucleophiles: Implications for immune mediated toxicity
Naisbitt, Dean J.,Neill, Paul M.,Pirmohamed, Munir,Park, B. Kevin
, p. 1511 - 1516 (1996)
Sulphamethoxazole hydroxylamine (SMX-NHOH) and nitroso sulphamethoxazole (SMX-NO) were prepared by a modified literature procedure. SMX-NO produced a complex set of unstable intermediates with sulphur nucleophiles, but did not react with amino containing compounds. No reactions were observed between sulphamethoxazole (SMX) / SMX-NHOH and the nucleophiles used in this study. Thus antigens formed from N-oxidation of SMX are likely to be unstable in vivo.
Reactive oxygen species generation and its role in the differential cytotoxicity of the arylhydroxylamine metabolites of sulfamethoxazole and dapsone in normal human epidermal keratinocytes
Vyas, Piyush M.,Roychowdhury, Sanjoy,Woster, Patrick M.,Svensson, Craig K.
, p. 275 - 286 (2007/10/03)
Cutaneous drug reactions (CDR) are responsible for numerous minor to life-threatening complications. Though the exact mechanism for CDR is not completely understood, evidence suggests that bioactivation of drugs to reactive oxygen or nitrogen species is a
