1146-44-7

Basic information

• Product Name: S-(4-chlorophenyl) 4-chlorobenzenesulfonothioate
• Synonyms: S-(4-Chlorophenyl) 4-chlorobenzenesulfonothioate
• CAS NO: 1146-44-7
• Molecular Formula: C₁₂H₈Cl₂O₂S₂
• Molecular Weight: 319.2267
• Mol File: 1146-44-7.mol
• Article Data: 53

Chemical Properties

• Boiling Point: 459.9°C at 760 mmHg
• Flash Point: 231.9°C
• Density: 1.54g/cm³
• Vapor Pressure: 3.33E-08mmHg at 25°C
• Refractive Index: 1.679
• CAS DataBase Reference: S-(4-chlorophenyl) 4-chlorobenzenesulfonothioate(CAS DataBase Reference)
• NIST Chemistry Reference: S-(4-chlorophenyl) 4-chlorobenzenesulfonothioate(1146-44-7)
• EPA Substance Registry System: S-(4-chlorophenyl) 4-chlorobenzenesulfonothioate(1146-44-7)

Safety Data

• Hazardous Substances Data: 1146-44-7(Hazardous Substances Data)

Upstream product

• 873-77-8 (4-chlorphenyl)magnesium bromide 
• 933-01-7 4-chloro-benzenesulfenyl chloride 
• 14752-66-0 sodium p-chlorobenzenesulphinate 
• 106-54-7 p-Chlorothiophenol 
• 119072-55-8 tert-butylisonitrile 
• 2901-92-0 p-chlorophenylsulfinyl chloride 
• 96-09-3 styrene oxide 
• 2751-25-9 p-chlorophenylsulfonyl hydrazide 
• 32017-76-8 (+/-)-2-(4-bromophenyl)oxirane 
• 2788-86-5 4-Chlorostyrene oxide 
• 81290-20-2 (trifluoromethyl)trimethylsilane 
• 98-60-2 4-chlorobenzenesulfonyl chloride 
• 1950-68-1 4-methoxybenzenesulfonyl hydrazide 
• 673-41-6 p-chlorobenzenediazonium tetrafluoroborate 

Downstream Products

• 98-64-6 4-Chlorobenzenesulfonamide 
• 1142-19-4 4,4'-dichlorodiphenyl disulfide 
• 106-54-7 p-Chlorothiophenol 
• 349-89-3 p-chlorobenzenesulfonyl fluoride 
• 7058-22-2 1-(benzylsulfonyl)-4-chlorobenzene 
• 122127-55-3 1,4-bis(4-chlorophenylthio)-2,3,5,6-tetrafluorobenzene 
• 16495-77-5 [(4-chlorophenyl)thio]pentafluorobenzene 

Relevant articles and documents

Oxidative dimerization of sulfenyl chlorides into thiosulfonates under the action of hexamethylphosphoramide

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Copper-Catalyzed Aerobic Formation of Unstable Sulfinyl Radicals for the Synthesis of Sulfinates and Thiosulfonates

Copper-catalyzed aerobic coupling of thiols and alcohols affords sulfinates and thiosulfonates. These products are assumed to form via sulfinyl radicals which are not commonly found in oxidative coupling reactions of thiols. A reaction mechanism involving sulfinyl radicals is proposed, and mass and electron paramagnetic resonance (EPR) experimental results are provided.

Zinc dichromate trihydrate (ZnCrmiddot;3H) as an efficient reagent for the one-pot synthesis of thiosulfonates from thiols

ZnCrH is a readily available and efficient reagent for the one-pot synthesis of a variety of thiosulfonates by chemoselective oxidation of thiols. Georg Thieme Verlag Stuttgart New York.

Direct conversion of sulfinamides to thiosulfonates without the use of additional redox agents under metal-free conditions

Direct conversion of sulfinamides to thiosulfonates is described. Without the use of additional redox agents, the reaction proceeds smoothly in the presence of TFA under metal-free conditions. This protocol possesses many advantages such as odourless and stable starting materials, broad substrate scope, selective synthesis, and mild reaction conditions. This journal is

Transition-Metal-Free Synthesis of Aryl Trifluoromethyl Thioethers through Indirect Trifluoromethylthiolation of Sodium Arylsulfinate with TMSCF3

Herein, we report an indirect trifluoromethylthiolation of sodium arylsulfinates. This transition-metal-free reaction significantly provides an environmentally friendly and practical synthetic method for aryl trifluoromethyl thioethers using commercial Ruppert-Prakash reagent TMSCF3. This approach is also a potential alternative to the current industrial production method owing to facile substrates, excellent functional group compatibility, and operational simplicity.

Dual Roles of Rongalite: Reductive Coupling Reaction to Construct Thiosulfonates Using Sulfonyl Hydrazides

A tunable and practical transformation of structurally diverse sulfonyl hydrazides into thiosulfonates in the presence of Rongalite (NaHSO 2·CH 2O) was developed. Transition-metal-free conditions, operational simplicity, and readily available reagents are the striking features of this protocol. It is the first example for the synthesis of thiosulfonates using sulfonyl hydrazides with the assistance of reductant. Additionally, the mechanistic studies revealed that this transformation probably undergoes via a reducing-coupling pathway.