114604-96-5Relevant articles and documents
Synthesis of Indole- and Pyrrole-Fused Seven-Membered Nitrogen Heterocycles via Acid-Base Switchable Cyclization Involving Cleavage of Amide C?N Bonds
Hao, Yanke,Zhou, Pan,Niu, Kaikai,Song, Hongjian,Liu, Yuxiu,Zhang, Jingjing,Wang, Qingmin
supporting information, p. 281 - 285 (2021/11/09)
We report the method for synthesis of indole- and pyrrole-fused seven-membered nitrogen heterocycles by means of acid-base switchable cyclization reactions. The reactions involved cleavage of amide C?N bonds, chemoselective N-1 or C-3 acylation, and 1,4-M
ALLOSTERIC EGFR INHIBITORS AND METHODS OF USE THEREOF
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Page/Page column 76, (2021/12/31)
The disclosure relates to compounds that act as allosteric inhibitors of epidermal growth factor receptor (EGFR); pharmaceutical compositions comprising the compounds; and methods of treating or preventing kinase-mediated disorders, including cancer and other proliferation diseases.
A Unified Strategy for the Synthesis of β-Carbolines, γ-Carbolines, and Other Fused Azaheteroaromatics under Mild, Metal-Free Conditions
Uredi, Dilipkumar,Motati, Damoder Reddy,Blake Watkins
supporting information, p. 6336 - 6339 (2018/10/15)
An efficient, unified approach for the synthesis of β-carbolines, γ-carbolines, and other fused azaheteroaromatics has been realized under metal-free conditions, from propargylic amines and (hetero)aromatic aldehydes. This unified strategy provides β- and
