114607-46-4 Usage
Description
Acitazanolast, also known as 2-((3-(1H-Tetrazol-5-yl)phenyl)-amino)-2-oxoacetic acid, is a chemical compound with potential applications in the pharmaceutical and biotechnology industries. It is characterized by its unique molecular structure, which allows it to interact with various biological targets and pathways.
Uses
Used in Pharmaceutical Industry:
Acitazanolast is used as a biological probe for identifying mechanisms-of-action targets for drugs and drug candidates. Its unique molecular structure enables it to interact with specific biological targets, providing valuable insights into the underlying mechanisms of various diseases and potential therapeutic interventions.
Used in Biotechnology Industry:
In the biotechnology sector, Acitazanolast can be employed as a tool for studying the interactions between biological molecules and their targets. This can help researchers understand the complex networks of cellular processes and identify potential therapeutic targets for the development of new drugs and treatments.
Originator
Zepelin ,Kowa
Manufacturing Process
2 Methods of preparation of 3-(1H-tetrazol-5-yl)oxanilic acid:
1. 5.0 g of 3-(1H-tetrazol-5-yl)aniline was dissolved in 25 ml of N,Ndimethylformamide,
followed by adding 5.68 g of triethylamine. Then, 5.64 g
of ether oxalyl chloride was dropwise added to the solution while cooling in ice
water. After completion of the dropwise addition, the reaction temperature
was slowly raised up to room temperature and the reaction was continued for
15 h. After the reaction was completed, the reaction mixture was poured into
100 ml of ice water and crystals separated out from the solution was filtered
off to obtain 8.3 g of ethyl 3-(1H-tetrazol-5-yl)oxanilate (yield 94.1%),
melting point 192°-l93°C (recrystallized from acetone/n-hexane).
The ethyl 3-(1H-tetrazol-5-yl)oxanilate (5.0 g), was dissolved in 35 ml of
ethanol and 100 ml of 0.5 N sodium hydroxide was dropwise added thereto
under water cooling. After the dropwise addition, the reaction temperature
was slowly raised up to room temperature and under such condition, the
reaction was carried out for 3 h. This solution was dropwise added to 70 ml of
4 N hydrochloric acid at room temperature. Thereafter, the solution was
stirred for 1 h and crystals separated out from the solution was filtered off.
The resultant crystals were washed with water and 3.9 g of 3-(1H-tetrazol-5-
yl)oxanilic acid was recovered (yield 87.4%), melting point 241°-243°C (dec.
recrystallized from isopropyl).
2. Oxalyl chloride (12.0 g) was dissolved in 50 ml of anhydrous
dimethoxyethane. To this solution a solution of 3-(1H-tetrazol-5-yl)aniline (5.0
g) in 250 ml of anhydrous dimethoxyethane was dropwise added over 3 h at
room temperature while stirring. Insolubles were removed by filtering the
solution, then 50 ml of water was gradually added to the reaction mixture
under ice cooling and stirring was continued for 1 h at room temperature.
Then, 500 ml of ethyl acetate was added thereto to carry out extraction, the
extract was washed with water, dried over anhydrous sodium sulfate and then
the solvent was distilled off to obtain 5.4 g of the 3-(1H-tetrazol-5- yl)oxanilic
acid (yield 74.8%), melting point 241°-243°C (dec. recrystallized from
isopropyl).
Therapeutic Function
Anti-asthmatic, Antiallergic, Bronchodilator
Check Digit Verification of cas no
The CAS Registry Mumber 114607-46-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,4,6,0 and 7 respectively; the second part has 2 digits, 4 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 114607-46:
(8*1)+(7*1)+(6*4)+(5*6)+(4*0)+(3*7)+(2*4)+(1*6)=104
104 % 10 = 4
So 114607-46-4 is a valid CAS Registry Number.
InChI:InChI=1/C9H7N5O3/c15-8(9(16)17)10-6-3-1-2-5(4-6)7-11-13-14-12-7/h1-4H,(H,10,15)(H,16,17)(H,11,12,13,14)
114607-46-4Relevant articles and documents
3-(1H-tetrazol-5-yl)oxanilic acid and salts thereof, method for preparing the same and pharmaceutical compositions containing the compound
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, (2008/06/13)
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3-(1H-tetrazol-5-y1)oxanilic acid and salts thereof and pharmaceutical compositions containing them
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, (2008/06/13)
A new compound, 3-(1H-tetrazol-5-yl)oxanilic acid and pharmaceutically acceptable salts thereof are herein disclosed, which can be prepared by reacting 3-(1H-tetrazol-5-yl)aniline with a compound represented by the general formula: A--CO--CO--B (wherein A
