1146365-23-2

Basic information

• Product Name: 5-((4-(trifluoromethyl)benzylamino)methyl)quinolin-8-ol
• Synonyms: 5-((4-(trifluoromethyl)benzylamino)methyl)quinolin-8-ol
• CAS NO: 1146365-23-2
• Molecular Weight: 332.325
• Mol File: 1146365-23-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 5-((4-(trifluoromethyl)benzylamino)methyl)quinolin-8-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 5-((4-(trifluoromethyl)benzylamino)methyl)quinolin-8-ol(1146365-23-2)
• EPA Substance Registry System: 5-((4-(trifluoromethyl)benzylamino)methyl)quinolin-8-ol(1146365-23-2)

Safety Data

• Hazardous Substances Data: 1146365-23-2(Hazardous Substances Data)

Upstream product

• 1146365-12-9 JLK 1486 
• 1849-36-1 para-nitrobenzenethiol 
• 3300-51-4 p-Trifluoromethylbenzylamine 
• 34619-03-9 tert-butyldicarbonate 

Downstream Products

• 3300-51-4 p-Trifluoromethylbenzylamine 

Relevant articles and documents

PPAR AGONIST COMPOSITIONS AND METHODS OF USE

Method for treating or preventing a PPAR-responsive condition in a subject, comprising administering to the subject a PPAR agonist that comprises a 8-hydroxyquinoline-methylene-N- group in an amount effective to activate a PPAR polypeptide.

Discovery of a new family of bis-8-hydroxyquinoline substituted benzylamines with pro-apoptotic activity in cancer cells: Synthesis, structure-activity relationship, and action mechanism studies

Bis-8-hydroxyquinoline substituted benzylamines have been synthesized and screened for their antitumor activity on KB3 cell line model. Synthesis of this series of new analogues was accomplished using a one pot specific methodology which allows the synthesis of both bis- and mono-8-hydroxyquinoline substituted benzylamines. Among the synthesized compounds two compounds (4a and 5a), respectively, named JLK 1472 and JLK 1486, were particularly potent on KB3 cell line. Their CC50 values being, respectively, 2.6 and 1.3 nM. Screened on a panel of cell lines showing various phenotype alterations, both compounds were found inactive on some cell lines such as PC3 (prostate cell line) and SF268 (neuroblastoma cell line) while highly active on other different cell lines. Mechanistic studies reveal that these two analogues did not affect tubulin and microtubules neither they exert a proteasomal inhibition effect. In contrast 4a and 5a activate specifically caspase 3/7 and not caspase 8 and 9, suggesting that their biological target should be located upstream from caspase 3/7. Moreover their cytotoxic effect is potentiated by the pro-apoptotic effects of TRAIL.