114655-02-6Relevant articles and documents
Paclitaxel prodrugs with sustained release and high solubility in poly(ethylene glycol)-b-poly(ε-caprolactone) micelle nanocarriers: Pharmacokinetic disposition, tolerability, and cytotoxicity
Forrest, M. Laird,Yanez, Jaime A.,Remsberg, Connie M.,Ohgami, Yusuke,Kwon, Glen S.,Davies, Neal M.
, p. 194 - 206 (2008)
Purpose. Develop a Cremophor and solvent free formulation of paclitaxel using amphiphilic block co-polymer micelles of poly(ethylene glycol)-b-poly(ε-caprolactone) (PEG-b-PCL) and characterize their release, solubility, cytotoxicity, tolerability, and dis
Paclitaxel-functionalized gold nanoparticles
Gibson, Jacob D.,Khanal, Bishnu P.,Zubarev, Eugene R.
, p. 11653 - 11661 (2007)
Here we describe the first example of 2 nm gold nanoparticles (Au NPs) covalently functionalized with a chemotherapeutic drug, paclitaxel. The synthetic strategy involves the attachment of a flexible hexaethylene glycol linker at the C-7 position of pacli
Ferrocenyl Paclitaxel and Docetaxel Derivatives: Impact of an Organometallic Moiety on the Mode of Action of Taxanes
Wieczorek, Anna,B?au?, Andrzej,?al, Aleksandra,Arabshahi, Homayon John,Reynisson, Jóhannes,Hartinger, Christian G.,Rychlik, B?a?ej,Pla?uk, Damian
, p. 11413 - 11421 (2016)
A series of ferrocenyl analogues and derivatives of paclitaxel and docetaxel were synthesised and assayed for their antiproliferative/cytotoxic effects, impact on the cell cycle distribution and ability to induce tubulin polymerisation. The replacement of the 3′-N-benzoyl group of paclitaxel with a ferrocenoyl moiety, in particular, led to formation of an analogue that was at least one order of magnitude more potent in terms of antiproliferative activity than the parent compound (IC50values of 0.11 versus 1.11 μm, respectively), but still preserved the classical taxane mode of action, that is, microtubule stabilisation leading to mitotic arrest. Molecular docking studies revealed an unexpected binding pocket in the tubulin structure for the ferrocenoyl group introduced in the paclitaxel backbone.
Synthesis and Biological Investigation of Bile Acid-Paclitaxel Hybrids
Casciano, Fabio,Marchesi, Elena,Melloni, Elisabetta,Navacchia, Maria Luisa,Perrone, Daniela,Preti, Lorenzo,Rimondi, Erika,Romani, Arianna,Secchiero, Paola
, (2022/01/20)
Chenodeoxycholic acid and ursodeoxycholic acid (CDCA and UDCA, respectively) have been conjugated with paclitaxel (PTX) anticancer drugs through a high-yield condensation reaction. Bile acid-PTX hybrids (BA-PTX) have been investigated for their pro-apopto
Taxol-DHA-dextran coupling polymer, synthetic method thereof and application of polymer
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Paragraph 0060; 0139; 0154-0156, (2019/10/01)
The invention provides a taxol-DHA-dextran coupling polymer, a synthetic method thereof and an application of the polymer, and belongs to the technical field of biological medicines. According to thepolymer, polysaccharides serve as polymer drug-loaded frameworks, so that an anti-tumor drug-polysaccharide passive targeted coupling polymer is prepared, taxol can be passively targeted into a tumortissue by the aid of an EPR effect, and an anti-tumor function is played. Water solubility and biocompatibility of taxol medicines can be increased, accumulation of anti-tumor medicines in the tumor tissue can be increased under the passive targeted action, general side effect and nervous side effect of the taxol medicines are reduced, and the polymer has good practical application values.
