114670-74-5 Usage
Description
4-(3-Fluorophenyl)semicarbazide, with the molecular formula C7H8FN3O, is a semicarbazide derivative featuring a fluorophenyl group attached to a semicarbazide moiety. This chemical compound holds potential in medicinal chemistry and pharmaceutical research as a building block for synthesizing bioactive compounds. It also has potential uses in organic synthesis and as a chemical intermediate, with ongoing investigation and development into its properties and specific applications in various industrial and research settings.
Uses
Used in Pharmaceutical Research:
4-(3-Fluorophenyl)semicarbazide is used as a building block for the synthesis of bioactive compounds, contributing to the development of new pharmaceuticals with potential therapeutic applications.
Used in Medicinal Chemistry:
As a semicarbazide derivative, 4-(3-Fluorophenyl)semicarbazide is utilized in medicinal chemistry for the creation of novel compounds with potential medicinal properties, enhancing the discovery of new drugs and treatments.
Used in Organic Synthesis:
4-(3-Fluorophenyl)semicarbazide serves as a chemical intermediate in organic synthesis, enabling the production of a variety of organic compounds for different applications.
Used in Chemical Intermediates:
In the realm of chemical intermediates, 4-(3-Fluorophenyl)semicarbazide is employed to facilitate the synthesis of other complex molecules, playing a crucial role in the development of new chemical entities.
Check Digit Verification of cas no
The CAS Registry Mumber 114670-74-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,4,6,7 and 0 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 114670-74:
(8*1)+(7*1)+(6*4)+(5*6)+(4*7)+(3*0)+(2*7)+(1*4)=115
115 % 10 = 5
So 114670-74-5 is a valid CAS Registry Number.
InChI:InChI=1/C7H8FN3O/c8-5-2-1-3-6(4-5)10-7(12)11-9/h1-4H,9H2,(H2,10,11,12)
114670-74-5Relevant articles and documents
Design, synthesis, and biological evaluation of sorafenib derivatives containing indole (ketone) semicarbazide analogs as antitumor agents
Li, Wen,Qi, Ya-Yun,Wang, Yuan-Yuan,Gan, Yi-Yuan,Shao, Li-Hui,Zhang, Li-Qiong,Tang, Zhen-Hua,Zhu, Mei,Tang, Si-Yu,Wang, Zhen-Chao,Ouyang, Gui-Ping
, p. 2548 - 2560 (2020/04/02)
A series of new sorafenib derivatives was designed and synthesized. The antiproliferative activity of the synthesized compounds against human lung cancer cell (A549), human pancreatic cancer cell (PC-3), human leukemia cell (K562), and human hepatoma cell (SMMC-7721) was evaluated by MTT assay. The results revealed that several compounds displayed more significant antitumor activities than commercial anticancer agent sorafenib against SMMC-7721. In addition, compounds 7a, 7g, 7l, 7m, and 7p represented obvious growth inhibition with IC50 values of 1-9 μM against four cancer cell lines, demonstrating more predominant activities against cancer cells as compared to sorafenib. Furthermore, some structure-activity relationships have also been established. Compounds containing indole and benzene ring substituted by halogen showed better activity than sorafenib. Wound healing assay suggested that cells would be targeted on their migratory capacity by 7g, potentially affecting the migration activity of these tumors. The effects of A549 and PC-3 cell apoptosis induced by compound 7g were significantly increased compared with sorafenib. Importantly, the result of western blot assay showed that 7g inhibited cell growth by suppressing the activity of EGFR, especially the expression of p-EGFR (Tyr1068).
