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114676-53-8

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114676-53-8 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 114676-53-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,4,6,7 and 6 respectively; the second part has 2 digits, 5 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 114676-53:
(8*1)+(7*1)+(6*4)+(5*6)+(4*7)+(3*6)+(2*5)+(1*3)=128
128 % 10 = 8
So 114676-53-8 is a valid CAS Registry Number.

114676-53-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name (2R,4R)-methyl 1-benzyl-4-hydroxypyrrolidine-2-carboxylate

1.2 Other means of identification

Product number -
Other names methyl (2R,4R)-1-benzyl-4-hydroxypyrrolidine-2-carboxylate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:114676-53-8 SDS

114676-53-8Relevant articles and documents

DIPEPTIDE PIPERIDINE DERIVATIVES

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, (2019/10/17)

The disclosure relates to pharmaceutical compositions, to methods of preparing such compositions, and to methods for using such compositions for treating or preventing a disease or condition associated with arginase activity.

A sub-milligram-synthesis protocol for in vitro screening of HDAC11 inhibitors

Tian, Yinping,Jin, Jin,Wang, Congying,Lv, Wenhui,Li, Xuewei,Che, Xiaona,Gong, Yanchao,Li, Yanjun,Li, Quanli,Hou, Jingli,Wang, Peng G.,Shen, Jie

, p. 2434 - 2437 (2016/07/07)

This work demonstrated the high efficiency of a sub-milligram-synthesis based medicinal chemistry method. Totally 72 compounds, consisting a tri-substituted pyrrolidine core, were prepared. Around 0.1 mg of each compound was solid-phase synthesized. Based on the additive property of UV absorptions of unconjugated chromophores of a molecule, these compounds were quantified by UV measurement. A hit, whose IC50 value was 1.2 μM in HDAC11 inhibition assays, highlights the applicability of the approach reported here in future optimization works.

COMPOUNDS

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Page/Page column 187, (2015/09/23)

The present invention relates to novel compounds that inhibit LRRK2 kinase activity, processes for their preparation, to compositions containing them and to their use in the treatment of or prevention of diseases characterized by LRRK2 kinase activity, for example Parkinson's disease, Alzheimer's disease and amyotrophic lateral sclerosis (ALS).

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