1146977-93-6

Basic information

• Product Name: Atorvastatin Ethyl Ester
• Synonyms: Atorvastatin Ethyl Ester;(βR,δR)-2-(4-Fluorophenyl)-β,δ-dihydroxy-5-(1-Methylethyl)-3-phenyl-4-[(phenylaMino)carbonyl]-1H-pyrrole-1-heptanoic Acid Ethyl Ester;Atorvastatin Acid Ethyl Ester;Atorvastatin Ethyl Ester Impurity;(3R,5R)-7-[3-(Phenylcarbamoyl)-5-(4-fluorophenyl)-2-isopropyl-4-phenyl-1H-pyrrol-1-yl]-3,5-dihydroxyheptanoic acid ethyl ester
• CAS NO: 1146977-93-6
• Molecular Formula: C₃₅H₃₉FN₂O₅
• Molecular Weight: 586.6929632
• Product Categories: Aromatics;Chiral Reagents;Impurities;Intermediates & Fine Chemicals;Pharmaceuticals
• Mol File: 1146977-93-6.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 712.0±60.0 °C(Predicted)
• Appearance: /
• Density: 1.19±0.1 g/cm3(Predicted)
• Storage Temp.: -20°C Freezer, Under Inert Atmosphere
• Solubility: Chloroform (Slightly), DMSO (Slightly)
• PKA: 13.57±0.70(Predicted)
• CAS DataBase Reference: Atorvastatin Ethyl Ester(CAS DataBase Reference)
• NIST Chemistry Reference: Atorvastatin Ethyl Ester(1146977-93-6)
• EPA Substance Registry System: Atorvastatin Ethyl Ester(1146977-93-6)

Safety Data

• Hazardous Substances Data: 1146977-93-6(Hazardous Substances Data)

Usage

Chemical Properties

White Solid

Upstream product

• 64-17-5 ethanol 
• 134523-03-8 lipitor 
• 134523-01-6 atorvastatin sodium 
• 1146977-92-5 (R)-ethyl-7-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-phenylcarbamoyl-1H-pyrrol-1-yl)-5-hydroxy-3-oxoheptanoate 

Downstream Products

• 134523-07-2 (-)-(4S)-trans-2-(4-fluorophenyl)-5-(1-methylethyl)-N,3-diphenyl-1-<(tetrahydro-4-hydroxy-2-oxo-2H-pyran-6-yl)ethyl>-1H-pyrrole-4-carboxamide 
• 134523-01-6 atorvastatin sodium 
• 134523-00-5 atorvastatin 

Relevant articles and documents

Discovery of atorvastatin as a tetramer stabilizer of nuclear receptor RXRα through structure-based virtual screening

Retinoid X receptor alpha (RXRα), a central member of the nuclear receptor superfamily and a key regulator of many signal transduction pathways, has been an attractive drug target. We previously discovered that an N-terminally truncated form of RXRα can b

Synthesis and evaluation of atorvastatin esters as prodrugs metabolically activated by human carboxylesterases

We synthesized 11 kinds of prodrug with an esterified carboxylic acid moiety of atorvastatin in moderate to high yields. We discovered that they underwent metabolic activation specifically by the human carboxylesterase 1 (CES1) isozyme. The results sugges

PROCESS FOR THE PREPARATION OF ATORVASTATIN

The present invention relates to a process for preparing the cholesterol biosynthesis inhibitor atorvastatin, (3R,5R)-7-[2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4- (phenylcarbamoyl)-lH-pyrrol-l-yl]-3,5-dihydroxyheptanoic acid calcium salt, which comprises