1147271-25-7 Usage
Chemical Class
Indeno[1,2-d]pyrimidine derivatives
Heterocyclic Core
Indeno[1,2-d]pyrimidine
Functional Groups
Amino group at the 2-position
Morpholinoethoxy group at the 8-position
Phenyl group at the 4-position
Biological Activities
Antitumor: Potential for combating tumors.
Antiviral: Potential for inhibiting viral activity.
Applications
Medicinal Chemistry: Utilized in drug development.
Value
Diverse Biological Activities: Makes it versatile for medicinal applications.
Unique Structure: Offers potential for novel drug development.
Potential Uses
Drug Development: Targeting various diseases.
Check Digit Verification of cas no
The CAS Registry Mumber 1147271-25-7 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,4,7,2,7 and 1 respectively; the second part has 2 digits, 2 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1147271-25:
(9*1)+(8*1)+(7*4)+(6*7)+(5*2)+(4*7)+(3*1)+(2*2)+(1*5)=137
137 % 10 = 7
So 1147271-25-7 is a valid CAS Registry Number.
1147271-25-7Relevant articles and documents
Optimization of arylindenopyrimidines as potent adenosine A2A/A1 antagonists
Shook, Brian C.,Rassnick, Stefanie,Chakravarty, Devraj,Wallace, Nathaniel,Ault, Mark,Crooke, Jeffrey,Barbay, J. Kent,Wang, Aihua,Leonard, Kristi,Powell, Mark T.,Alford, Vernon,Hall, Daniel,Rupert, Kenneth C.,Heintzelman, Geoffrey R.,Hansen, Kristen,Bullington, James L.,Scannevin, Robert H.,Carroll, Karen,Lampron, Lisa,Westover, Lori,Russell, Ronald,Branum, Shawn,Wells, Kenneth,Damon, Sandra,Youells, Scott,Beauchamp, Derek,Li, Xun,Rhodes, Kenneth,Jackson, Paul F.
scheme or table, p. 2868 - 2871 (2010/07/06)
Two reactive metabolites were identified in vivo for the dual A2A/A1 receptor antagonist 1. Two strategies were implemented to successfully mitigate the metabolic liabilities associated with 1. Optimization of the arylindenopyrimidines led to a number of amide, ether, and amino analogs having comparable in vitro and in vivo activity.
