114798-32-2

Basic information

• Product Name: [1,1'-Biphenyl]-2-carboxylicacid,4'-[[2-(1E)-1-buten-1-yl-4-chloro-5-(hydroxymethyl)-1H-imidazol-1-yl]methyl]-
• Synonyms: [1,1'-Biphenyl]-2-carboxylicacid, 4'-[[2-(1-butenyl)-4-chloro-5-(hydroxymethyl)-1H-imidazol-1-yl]methyl]-,(E)-; [1,1'-Biphenyl]-2-carboxylic acid,4'-[[2-(1E)-1-butenyl-4-chloro-5-(hydroxymethyl)-1H-imidazol-1-yl]methyl]-(9CI); EXP 9270
• CAS NO: 114798-32-2
• Molecular Formula: C22H21 Cl N2 O3
• Molecular Weight: 396.873
• Mol File: 114798-32-2.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: [1,1'-Biphenyl]-2-carboxylicacid,4'-[[2-(1E)-1-buten-1-yl-4-chloro-5-(hydroxymethyl)-1H-imidazol-1-yl]methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: [1,1'-Biphenyl]-2-carboxylicacid,4'-[[2-(1E)-1-buten-1-yl-4-chloro-5-(hydroxymethyl)-1H-imidazol-1-yl]methyl]-(114798-32-2)
• EPA Substance Registry System: [1,1'-Biphenyl]-2-carboxylicacid,4'-[[2-(1E)-1-buten-1-yl-4-chloro-5-(hydroxymethyl)-1H-imidazol-1-yl]methyl]-(114798-32-2)

Safety Data

• Hazardous Substances Data: 114798-32-2(Hazardous Substances Data)

Usage

Description

[1,1'-Biphenyl]-2-carboxylic acid,4'-[[2-(1E)-1-buten-1-yl-4-chloro-5-(hydroxymethyl)-1H-imidazol-1-yl]methyl]is a complex organic compound characterized by its biphenyl core, carboxylic acid functional group, and various substituents. [1,1'-Biphenyl]-2-carboxylicacid,4'-[[2-(1E)-1-buten-1-yl-4-chloro-5-(hydroxymethyl)-1H-imidazol-1-yl]methyl]features a 1E-1-buten-1-yl chain, a 4-chloro-5-hydroxymethyl-1H-imidazol-1-yl group, and a methyl group. Its diverse chemical structure and properties suggest potential applications across different industries, including pharmaceuticals, agrochemicals, and materials science.

Uses

Used in Pharmaceutical Industry:
[1,1'-Biphenyl]-2-carboxylic acid,4'-[[2-(1E)-1-buten-1-yl-4-chloro-5-(hydroxymethyl)-1H-imidazol-1-yl]methyl]is used as a pharmaceutical compound for its potential therapeutic applications. [1,1'-Biphenyl]-2-carboxylicacid,4'-[[2-(1E)-1-buten-1-yl-4-chloro-5-(hydroxymethyl)-1H-imidazol-1-yl]methyl]-'s unique structure may allow it to interact with various biological targets, making it a candidate for the development of new drugs.
Used in Agrochemical Industry:
In the agrochemical industry, [1,1'-Biphenyl]-2-carboxylic acid,4'-[[2-(1E)-1-buten-1-yl-4-chloro-5-(hydroxymethyl)-1H-imidazol-1-yl]methyl]is used as a chemical building block for the synthesis of novel agrochemicals. Its structural diversity may contribute to the development of new pesticides, herbicides, or other agricultural products.
Used in Materials Science:
[1,1'-Biphenyl]-2-carboxylic acid,4'-[[2-(1E)-1-buten-1-yl-4-chloro-5-(hydroxymethyl)-1H-imidazol-1-yl]methyl]is used as a component in the development of advanced materials. Its unique chemical properties may be harnessed to create new materials with specific characteristics, such as improved mechanical strength, thermal stability, or chemical resistance.

Upstream product

• 114772-69-9 1-[(2'-Carbomethoxybiphenyl-4-yl)methyl]-2-(1-trans-butenyl)-4-chloro-5-hydroxymethylimidazole 
• 84392-32-5 4,4-dimethyl-2-(4'-methyl-biphenyl-2-yl)-4,5-dihydrooxazole 
• 114772-38-2 Methyl 4'-(bromomethyl)biphenyl-2-carboxylate 
• 74201-13-1 N-(2-hydroxy-1,1-dimethyl)-2-methoxybenzamide 
• 114772-34-8 methyl 4'-methylbiphenyl-2-carboxylate 
• 7148-03-0 o-tolylbenzoic acid 
• 610-97-9 o-iodo-methyl-benzoic acid 
• 624-31-7 4-tolyl iodide 
• 57598-33-1 2-(2-methoxyphenyl)-4,4-dimethyl-2-oxazoline 
• 114772-66-6 2-butyl-4-chloro-5-formyl-1-[(2'-methoxycarbonyl-1,1'-biphenyl-4-yl)methyl]-1H-imidazole 
• 114772-43-9 2-butyl-4-chloro-5-hydroxymethyl-1-[(2'-methoxycarbonyl-1,1'-biphenyl-4-yl)methyl]-1H-imidazole 
• 114772-67-7 1-[(2'-carbomethoxybiphenyl-4-yl)-methyl]-2-(1-bromobutyl)-4-chloroimidazole-5-carboxaldehyde 
• 114772-68-8 2-(1-trans-butenyl)-1-<(2'-carbomethoxybiphenyl-4-yl)methyl>-4-chloroimidazole-5-carboxaldehyde 
• 21615-34-9 2-Methoxybenzoyl chloride 

Relevant articles and documents

Use of an angiotensin II receptor antagonist for the preparation of drugs to increase the survival rate of renal transplant patients

The present invention relates to the use, for the preparation of drugs to increase the survival rate of transplant patients, including renal and heart transplant patients, of a therapeutically effective amount of an angiotension II receptor antagonist compound, such as the class of substituted imidazoles represented by formula (I) and in particular by losartan potassium, 2-butyl-4-chloro-[(2′-tetrazol-5-yl)biphenyl-4-il]methyl]-5-(hydroxymethyl)imidazole potassium salt.

Treatment of atherosclerosis with angiotensin II receptor blocking imidazoles

A method of treatment for atherosclerosis and/or reducing cholesterol using an angiotensin II antagonist. This method of treatment can be used in conjunction with the treatment of hypertension. Substituted imidazoles such as STR1 are useful as angiotensin II receptor antagonists for this method of treatment. A method of treatment for atherosclerosis and/or reducing cholesterol using an angiotensin II receptor antagonist in combination with an HMG-Co A reductase inhibitor. A method of treatment for atherosclerosis and/or reducing cholesterol using an angiotensin II receptor antagonist in combination with an HMG-Co A reductase inhibitor and an angiotensin converting enzyme inhibitor. Also within the scope of this invention are pharmaceutical compositions for this method of use.

Treatment of central nervous system disorders with imidazole angiotensin-II receptor antagonists

Substituted imidazoles such as 2-butyl-4-chloro-1-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methyl]-5-(hydroxymethyl)imidazole and 2-butyl-4-chloro-1-[(2'-carboxybiphenyl-4-yl)-methyl]-5-(hydroxymethyl)imidazole and pharmaceutically acceptable salts thereof are useful for treating central nervous system disorders, such as cognitive and learning disorders, mediated by angiotensin II.