1148-03-4

Basic information

• Product Name: 2-Propen-1-one, 1-(4-chloro-2-hydroxyphenyl)-3-phenyl-
• CAS NO: 1148-03-4
• Molecular Formula: C15H11ClO2
• Molecular Weight: 258.704
• Mol File: 1148-03-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-Propen-1-one, 1-(4-chloro-2-hydroxyphenyl)-3-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propen-1-one, 1-(4-chloro-2-hydroxyphenyl)-3-phenyl-(1148-03-4)
• EPA Substance Registry System: 2-Propen-1-one, 1-(4-chloro-2-hydroxyphenyl)-3-phenyl-(1148-03-4)

Safety Data

• Hazardous Substances Data: 1148-03-4(Hazardous Substances Data)

Upstream product

• 6921-66-0 4-chloro-2-hydroxy acetophenone 
• 100-52-7 benzaldehyde 

Downstream Products

• 3260-82-0 6-chloroaurone 
• 63483-33-0 6-chloro-3-phenyl-4-chromanone 
• 1148-48-7 7-chloro-2-phenyl-4H-1-benzopyran-4-one 

Relevant articles and documents

Ionic liquid mediated Cu-catalyzed cascade oxa-Michael-oxidation: Efficient synthesis of flavones under mild reaction conditions

Flavonoids are a class of natural products, found in a wide range of vascular plants and dietary components. Their low toxicity and extensive biological activities, including anti-cancer and anti-bacterial, have made them attractive candidates to serve as therapeutic agents for many diseases. Herein, we disclose a highly efficient synthetic method of CuI-catalyzed cascade oxa-Michael-oxidation, using chalcones as substrates, mediated by the ionic liquid [bmim][NTf2] at a low temperature. This efficient synthetic method has demonstrated high synthetic utility and can afford flavones in good to high yields (up to 98%).