1148010-41-6

Basic information

• Product Name: (E)-3-(3',4'-bis(benzyloxy)phenyl)-1-(2-hydroxyphenyl)prop-2-en-1-one
• Synonyms: (E)-3-(3',4'-bis(benzyloxy)phenyl)-1-(2-hydroxyphenyl)prop-2-en-1-one
• CAS NO: 1148010-41-6
• Molecular Weight: 436.507
• Mol File: 1148010-41-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (E)-3-(3',4'-bis(benzyloxy)phenyl)-1-(2-hydroxyphenyl)prop-2-en-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: (E)-3-(3',4'-bis(benzyloxy)phenyl)-1-(2-hydroxyphenyl)prop-2-en-1-one(1148010-41-6)
• EPA Substance Registry System: (E)-3-(3',4'-bis(benzyloxy)phenyl)-1-(2-hydroxyphenyl)prop-2-en-1-one(1148010-41-6)

Safety Data

• Hazardous Substances Data: 1148010-41-6(Hazardous Substances Data)

Upstream product

• 5447-02-9 3,4-dibenzyloxybenzaldehyde 
• 118-93-4 o-hydroxyacetophenone 

Downstream Products

• 307521-00-2 2-(3',4'-bis(benzyloxy)phenyl)-3-hydroxy-4H-chromen-4-one 
• 1239335-34-2 C₂₉H₂₆O₃ 

Relevant articles and documents

NOVEL ANALOGUES OF EPICATECHIN AND RELATED POLYPHENOLS

The present invention provides novel analogues of epicatechin and related polyphenols, their variously functionalized derivatives, process for preparation of the same, composition comprising these compounds and their method of use.

Inhibitory activity of prostaglandin E2 production by the synthetic 2′-hydroxychalcone analogues: Synthesis and SAR study

A series of 2′-hydroxychalcones has been synthesized and screened for their in vitro inhibitory activities of cyclooxygenase-2 catalyzed prostaglandin production from lipopolysaccharide-treated RAW 264.7 cells. Structure-activity relationship study suggested that inhibitory activity against prostaglandin E2 production was governed to a greater extent by the substituent on B ring of the chalcone, and most of the active compounds have at least two methoxy or benzyloxy groups on B ring. The relationship between chalcone structures and their PGE2 inhibitory activities was also interpreted by docking study on cyclooxygenase-2.