114826-34-5Relevant articles and documents
PREPARATION OF (20E)-21-METHOXYCARBONYL-5,14,20-PREGNATRIEN-3β-OL DERIVATIVES
Pouzar, Vladimir,Cerny, Ivan,Drasar, Pavel,Havel, Miroslav
, p. 1803 - 1810 (2007/10/02)
(20E)-21-Methoxycarbonyl-5,14,20-pregnatrien-3β-yl hydrogen butanedioate (XII) and (20E)-21-ethoxycarbonyl-5,14,20-pregnatrien-3β-yl hydrogen butanedioate (XIV) were prepared in nine steps from 3β-acetoxy-5,14-pregnadien-20-one (I).In the key intermediate, 20-(bis(4-methoxyphenyl)phenylmethoxy)-21-nor-5,14-pregnadien-3β-yl 2-(trimethylsilyl)ethyl butanedioate (VIII), the hydroxyl in position 20 was protected with 4,4'-dimethoxytrityl group and the succinate moiety with 2-(trimethylsilyl)ethyl group.