114849-77-3Relevant articles and documents
Aromatic aminations by heterogeneous Ni0/C catalysis
Lipshutz, Bruce H.,Ueda, Hiroshi
, p. 4492 - 4494 (2000)
Cost counts! And green chemistry is "in". Thus, for Pd0- or Ni0-catalyzed aminations of aryl halides, which are usually conducted under homogeneous conditions, a new methodology is disclosed which allows for amination reactions on less costly aryl chlorides mediated by an especially inexpensive heterogeneous catalyst, nickel-on-charcoal (Ni/C,see scheme; DPPF 00= 1,1′-bis(diphenylphosphanyl)ferrocene).
Palladium-catalyzed c(sp2)-n bond cross-coupling with triaryl phosphates
Chen, Zicong,Chen, Xiangmeng,So, Chau Ming
, (2019/05/22)
The first general palladium-catalyzed amination of aryl phosphates is described. The combination of MorDalPhos with [Pd(-cinnamyl)Cl]2 enables the amination of electron-rich, electron-neutral, and electron-poor aryl phosphates with a board range of aromatic, aliphatic, and heterocyclic amines. Common functional groups such as ether, keto, ester, and nitrile show an excellent compatibility in this reaction condition. The solvent-free amination reactions are also successful in both solid coupling partners. The gram-scale cross-coupling is achieved by this catalytic system.
One-pot, modular approach to functionalized ketones via nucleophilic addition/Buchwald-Hartwig amination strategy
De Jong, Jorn,Heijnen, Dorus,Helbert, Hugo,Feringa, Ben L.
, p. 2908 - 2911 (2019/03/17)
A general one-pot procedure for the 1,2-addition of organolithium reagents to amides followed by the Buchwald-Hartwig amination with in situ released lithium amides is presented. In this work amides are used as masked ketones, revealed by the addition of organolithium reagents which generates a lithium amide, suitable for subsequent Buchwald-Hartwig coupling in the presence of a palladium catalyst. This methodology allows for rapid, efficient and atom economic synthesis of aminoarylketones in good yields.
