114873-13-1 Usage
Description
BOC-D-3,4-Dichlorophe, also known as N-Boc-D-3,4-dichlorophenylalanine, is a white to off-white powder with specific chemical properties. It is a derivative of phenylalanine, an essential amino acid, with a chloro substitution at the 3 and 4 positions on the phenyl ring and a Boc (tert-butoxycarbonyl) protecting group. BOC-D-3,4-Dichlorophe is significant in the pharmaceutical and chemical industries due to its potential applications in the development of various therapeutic agents.
Uses
BOC-D-3,4-Dichlorophe is used as a key intermediate in the synthesis of pharmaceutical compounds, particularly for the development of inhibitors and receptor antagonists.
Used in Pharmaceutical Industry:
BOC-D-3,4-Dichlorophe is used as a building block for the preparation of fluorinated β-aminoacyl 1,2,4-triazolo[4,3-a]piperazine amides. These compounds serve as dipeptidyl peptidase IV (DPP-IV) inhibitors and are utilized as antidiabetic agents, helping to regulate blood sugar levels in patients with diabetes.
BOC-D-3,4-Dichlorophe is also used in the synthesis of N-[(R,R)-(E)-1-(3,4-dichlorobenzyl)-3-(2-oxoazepan-3-yl)carbamoyl]allyl-N-methyl-3,5-bis(trifluoromethyl)benzamide. BOC-D-3,4-Dichlorophe is a potent and orally active dual neurokinin NK1/NK2 receptor antagonist, which has potential applications in the treatment of various conditions, including pain, inflammation, and psychiatric disorders.
Check Digit Verification of cas no
The CAS Registry Mumber 114873-13-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,4,8,7 and 3 respectively; the second part has 2 digits, 1 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 114873-13:
(8*1)+(7*1)+(6*4)+(5*8)+(4*7)+(3*3)+(2*1)+(1*3)=121
121 % 10 = 1
So 114873-13-1 is a valid CAS Registry Number.
InChI:InChI=1/C14H17Cl2NO4/c1-14(2,3)21-13(20)17-11(12(18)19)7-8-4-5-9(15)10(16)6-8/h4-6,11H,7H2,1-3H3,(H,17,20)(H,18,19)/t11-/m1/s1
114873-13-1Relevant articles and documents
Discovery of pyrrolopyrimidine inhibitors of Akt
Blake, James F.,Kallan, Nicholas C.,Xiao, Dengming,Xu, Rui,Bencsik, Josef R.,Skelton, Nicholas J.,Spencer, Keith L.,Mitchell, Ian S.,Woessner, Richard D.,Gloor, Susan L.,Risom, Tyler,Gross, Stefan D.,Martinson, Matthew,Morales, Tony H.,Vigers, Guy P.A.,Brandhuber, Barbara J.
scheme or table, p. 5607 - 5612 (2010/11/17)
The discovery and optimization of a series of pyrrolopyrimidine based protein kinase B (Pkb/Akt) inhibitors discovered via HTS and structure based drug design is reported. The compounds demonstrate potent inhibition of all three Akt isoforms and knockdown of phospho-PRAS40 levels in LNCaP cells and tumor xenografts.