114898-41-8

Basic information

• Product Name: 2-(4-chlorophenyl)-2-mercaptoacetic acid
• Synonyms: 2-(4-chlorophenyl)-2-mercaptoacetic acid
• CAS NO: 114898-41-8
• Molecular Weight: 202.661
• Mol File: 114898-41-8.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 2-(4-chlorophenyl)-2-mercaptoacetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-chlorophenyl)-2-mercaptoacetic acid(114898-41-8)
• EPA Substance Registry System: 2-(4-chlorophenyl)-2-mercaptoacetic acid(114898-41-8)

Safety Data

• Hazardous Substances Data: 114898-41-8(Hazardous Substances Data)

Upstream product

• 133692-27-0 methyl 2-(4-chlorophenyl)-2-mercaptoacetate 
• 24091-92-7 methyl 2-bromo-2-(4-chlorophenyl)acetate 
• 32174-34-8 methyl 4-chloromandelate 
• 114898-40-7 methyl 2-(acetylthio)-2-(4-chlorophenyl)acetate 
• 940952-13-6 S-acetyl-α-(p-chlorophenyl)-α-mercaptoacetic acid 

Downstream Products

• 124623-51-4 (2S,5S)-(-)-trans-5-(4-chlorophenyl)-3-methyl-2-(3-pyridyl)thiazolidin-4-one 
• 124623-50-3 (2S,5R)-(-)-cis-5-(4-chlorophenyl)-3-methyl-2-(3-pyridyl)thiazolidin-4-one 
• 124623-44-5 5-(4-chlorophenyl)-3-methyl-2-(pyridin-3-yl)thiazolidin-4-one 
• 940952-44-3 4-(p-chlorophenyl)-1,3,2-oxathiazolylium-5-olate 
• 124624-76-6 (R)-(4-chlorophenyl)sulfanyl acetic acid 
• 124624-74-4 (S)-(4-chlorophenyl)sulfanyl acetic acid 
• 133692-27-0 methyl 2-(4-chlorophenyl)-2-mercaptoacetate 
• 114898-02-1 (+/-)-cis-5-(4-Chlorophenyl)-3-methyl-2-(3-pyridyl)thiazolidin-4-one 
• 114898-02-1 (+/-)-trans-5-(4-chlorophenyl)-3-methyl-2-(3-pyridyl)thiazolidin-4-one 

Relevant articles and documents

New 4-aryl-1,3,2-oxathiazolylium-5-olates: Chemical synthesis and photochemical stability of a novel series of S-nitrosothiols

S-nitrosothiols (RSNOs) remain one of the most popular classes of NO-donating compounds due to their ability to release nitric oxide (NO) under non-enzymatic means whilst producing an inert disulphide by-product. However, alligning these compounds to the different biological fields of NO research has proved to be problematic due to the inherent instability of such compounds under a variety of conditions including heat, light and the presence of copper ions. 1,3,2-Oxathiazolylium-5-olates (OZOs) represent an interesting subclass of S-nitrosothiols that lock the –SNO moiety into a five membered heterocyclic ring in an attempt to improve the compound's overall stability. The synthesis of a novel series of halogen-containing OZOs was comprehensively studied resulting in a seven-step route and overall yields ranging between 21 and 37%. The photochemical stability of these compounds was assessed to determine if S-nitrosothiols locked within these mesoionic ring systems can offer greater stability and thereby release NO in a more controllable fashion than their non-cyclic counterparts.

Synthetic Study of the Highly Potent and Selective Anti-platelet Activating Factor Thiazolidin-4-one Agents and related Compounds

Stereoselective cyclo-condensation of α-sulfanylcarboxylic acids (or esters) 6 with N-methylarylimines 7 afforded the title compounds, 2-arylthiazolidin-4-ones, some of which exhibit highly potent anti-PAF activity.The reaction without added catalyst gave predominantly cis products, however, when titanium(IV) isopropoxide was added as catalyst trans products were predominantly formed.Allylation of 3-methyl-2-(3-pyridyl)thiazolidin-4-one 22 with allyl bromide using lithium amides gave the trans-5-allyl-2-(3-pyridyl)thiazolidin-4-one 23 with good selectivity.To study the stereostructure-activity relationship, the four optically active isomers of 3,5-dimethyl-2-(3-pyridyl)thiazolidin-4-one 4 and 5-(4-chlorophenyl)-3-methyl-2-(3-pyridyl)thiazolidin-4-one 5 were synthesized.The absolute configurations of compounds 4 and 5 were determined by X-ray analyses and 1H NMR measurements.Epimerization of the 5-position of compounds 4 and 5 was found to be effected by bases with high regioselectivity (>99percent), which was checked by a cross-over experiment using several optically active compounds.

Thiazolidin-4-one derivatives and acid addition salts thereof

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