114969-66-3Relevant articles and documents
Preparation method of 4-cyano-5-bromopyrimidine
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Paragraph 0035; 0039-0041; 0045-0047; 0051-0052, (2021/07/10)
The invention discloses a preparation method of 4-cyano-5-bromopyrimidine, the preparation method comprises the following steps: taking 4-chloro-5-bromopyrimidine (compound II) as a raw material, and carrying out bromine chlorine substitution reaction on the 4-chloro-5-bromopyrimidine (compound II) and trimethylbromosilane to generate 4, 5-dibromopyrimidine (compound III); the compound III and cuprous cyanide are subjected to a nucleophilic substitution reaction to generate 4-cyano-5-bromopyrimidine (compound I), and the yield of the two-step reaction can reach 70% or above.
Studies on Pyrimidine Derivatives. XXXIX. Site-Selectivity in the Reaction of 5-Substituted and 4,5-Disubstituted Pyrimidine N-Oxides with Trimethylsilyl Cynanide
Yamanaka, Hiroshi,Sakamoto, Takao,Nishimura, Sumiko,Sagi, Mataichi
, p. 3119 - 3126 (2007/10/02)
The site-selectivity in the modified Reissert-Henze reaction of 5-substituted and 4,5-disubstituted pyrimidine 1-oxides with trimethylsilyl cyanide was examined.The reaction of 5-substituted 4-methoxypyrimidine 1-oxides with trimethylsilyl cyanide gave exclusively 2-pyrimidinecarbonitriles in good yields without exception.On the other hand, the other 5-substituted and 4,5-disubstituted pyrimidine 1-oxides gave mainly 6-pyrimidinecarbonitriles.Keywords--site-selectivity; pyrimidine N-oxide; trimethylsilyl cyanide; Reissert-Henze reasction; pyrimidinecarbonitrile