114974-25-3

Basic information

• Product Name: 2-(5-Chloro-2-methoxyphenyl)-1-hydroxy-4-methyl-5-(3-pyridyl)imidazole
• CAS NO: 114974-25-3
• Molecular Weight: 315.759
• Mol File: 114974-25-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-(5-Chloro-2-methoxyphenyl)-1-hydroxy-4-methyl-5-(3-pyridyl)imidazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(5-Chloro-2-methoxyphenyl)-1-hydroxy-4-methyl-5-(3-pyridyl)imidazole(114974-25-3)
• EPA Substance Registry System: 2-(5-Chloro-2-methoxyphenyl)-1-hydroxy-4-methyl-5-(3-pyridyl)imidazole(114974-25-3)

Safety Data

• Hazardous Substances Data: 114974-25-3(Hazardous Substances Data)

Upstream product

• 6419-36-9 3-pyridineacetic acid hydrochloride 
• 6302-03-0 1-(pyridin-3-yl)-2-propanone 
• 65882-96-4 1-hydroxyimino-1-(3-pyridyl)-2-propanone 
• 7035-09-8 5-chloro-2-methoxybenzaldehyde 

Relevant articles and documents

Studies on antiplatelet agents. I. Synthesis and platelet inhibitory activity of 5-alkyl-2-aryl-4-pyridylimidazoles

5-Alkyl-2-aryl-4-pyridylimidazoles were synthesized and tested in rat ex vivo platelet aggregation studies. Among these compounds, 2-(2-fluorophenyl)-5-methyl-4-(3-pyridyl)imidazole (25) was most potent, and showed 98% inhibition at a dose of 10 mg/kg (p.o.). 25 had inhibitory activity on cyclooxygenase, thromboxane A2 (TXA2) synthetase, and phosphodiesterase, and also showed inhibited KCl-induced contraction of rat aorta. All compounds have little acute toxicity and appear to be free of adverse effects on the stomach.