1149755-71-4Relevant articles and documents
A designer axially chiral amino sulfonamide as an efficient organocatalyst for direct asymmetric mannich reactions of N-boc-protected imines
Kano, Taichi,Yamaguchi, Yukako,Maruoka, Keiji
, p. 1838 - 1840 (2009)
The moderate nucleophilicity of the axially chiral amino sulfonamide (S)-1 suppresses the problematic side reactions, including aldol reactions, in the asymmetric Mannich reaction of N-Boc-protected imines with aldehydes. The corresponding adducts are obtained in good yield and excellent stereoselectivity (see scheme; Boc=tert-butoxycarbonyl, Tf=trifluoromethanesulfonyl).