115-20-8Relevant articles and documents
Degradation pathways of trichloroethylene and 1,1,1-trichloroethane by Mycobacterium sp. TA27
Hashimoto, Akiko,Iwasaki, Kazuhiro,Nakasugi, Naou,Nakajima, Mutsuyasu,Yagi, Osami
, p. 385 - 390 (2002)
We analyzed the kinetics and metabolic pathways of trichloroethylene and 1,1,1-trichloroethane degradation by the ethane-utilizing Mycobacterium sp. TA27. The apparent Vmax and Km of trichloroethylene were 9.8 nmol min-1 m
Laser Photolysis/Laser-Induced Fluorescence Studies of the Reaction of OH with 1,1-Dichloroethane over an Extended Temperature Range
Jiang, Zhen,Taylor, Philip H.,Dellinger, Barry
, p. 8964 - 8966 (1992)
Absolute rate coefficients are determined for the gas-phase reaction of OH radicals with 1,1-dichloroethane over an extended temperature range using a laser photolysis/laser-induced fluorescence technique.Experiments were performed in a flow system at a total pressure of 740 +/- 10 Torr using He as diluent and carrier gas.The rate coefficients, obtained over the temperature range 294-800 K, exhibited pronounced non-Arrhenius behavior and were best described by the modified Arrhenius equation k(T)=(8.29 +/- 0.36) x 10-14(T/300)2.67exp cm3 molecule-1 s-1.Comparison of the data with one previous room-temperature measurement is presented.The temperature dependence of the data is compared with empirical and transition-state model calculations.The influence of C-H bond energy and Cl substitution is discussed.
High utility of Saccharomyces cerevisiae harboring rat liver cytochrome P450 1A2 cDNA in haloethanes dehalogenations
Yanagita, Kazutaka,Sagami, Ikuko,Shimizu, Toru
, p. 561 - 562 (1997)
Yeast harboring rat liver P450 1A2 efficiently degraded trichloroethylene, pentachloroethane and hexachloroethane. Since liver P450s catalyze degradation of thousands of chemicals, this method is promising for chemical-directed degradation of environmental pollutants.
A DMAP-catalyzed approach to the industrial-scale preparation of N -6-demethylated 9,10-dihydrolysergic acid methyl ester: A key cabergoline and pergolide precursor
asar, Zdenko,Mesar, Toma
supporting information, p. 378 - 385 (2015/04/21)
A scalable new approach for the preparation of N-6-demethylated 9,10-dihydrolysergic acid methyl ester using 2,2,2-trichloroethyl chloroformate was developed. A key discovery that enabled the efficient and industrial-scalable process is linked to the rigorous extrusion of water in the reaction system and application of an organic catalyst such as 4-(N,N-dimethylamino)pyridine (DMAP) instead of the alkali metal bicarbonate additives. Namely, in the previously known process, the concomitant presence of bicarbonates and traces of water triggers side reaction cycles that produce and accumulate hydrochloric acid and water. The former slows down the reaction. Moreover, these cycles cause the formation of multiple carbonate and alcohol-type side products to a significant extent that provide a low-quality N-6-demethylated product. All of these shortcomings are circumvented by the application of DMAP as a catalyst and the use of a reaction medium free of water. This approach allows operation on an industrial scale (51 kg batch) with higher yields, shorter reaction times, and improved product quality.
Practical and chemoselective reduction of acyl chloride to alcohol by borohydride in aqueous dichloromethane
Rajan, Ramya,Badgujar, Sachin,Kaur, Kamaljit,Malpani, Yashwardhan,Kanjilal, Pranab R.
experimental part, p. 2897 - 2907 (2010/11/18)
A simple methodology for the reduction of acid chlorides to their corresponding alcohols has been developed. Various carboxylic acids were converted to alcohols in excellent yields using NaBH4-K2CO3 in a mixed solvent system of dichloromethane and water (1:1) in the presence of a phase-transfer catalyst at low temperature. The importance of the work is its simplicity, selectivity, excellent yield, and very short reaction time. This new reduction condition has proved to be an excellent chemoselective method for a range of acid chlorides in the presence of various functional groups.