115-44-6

Basic information

• Product Name: TALBUTAL CIII (250 MG)
• Synonyms: TALBUTAL CIII (250 MG);2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-(1-methylpropyl)-5-(2-propenyl)-;2,4,6(1H,3H,5H)-Pyrimidinetrione, 5-(1-methypropyl)-5-(2-propenyl)-;5-(1-Methylpropyl)-5-(2-propenyl)-2,4,6(1H,3H,5H)-pyrimidinetrione;5-(1-methylpropyl)-5-(2-propenyl)-2,4-6(1h,3h,5h)-pyrimidinetrione;5-Allyl-5-(1-methylpropyl) barbituric acid;5-allyl-5-(1-methylpropyl)barbituricacid;5-Allyl-5-sec-butyl-2,4,6(1H,3H,5H)-pyrimidinetrione
• CAS NO: 115-44-6
• Molecular Formula: C₁₁H₁₆N₂O₃
• Molecular Weight: 224.25634
• EINECS: 204-090-4
• Product Categories: Heterocycles;Intermediates & Fine Chemicals;Neurochemicals;Pharmaceuticals
• Mol File: 115-44-6.mol
• Article Data: 0

Chemical Properties

• Melting Point: 108-110°
• Boiling Point: 365.66°C (rough estimate)
• Flash Point: °C
• Appearance: /
• Density: 1.1672 (rough estimate)
• Vapor Pressure: 0.000384mmHg at 25°C
• Refractive Index: 1.5000 (estimate)
• Water Solubility: 2.16g/L(temperature not stated)
• CAS DataBase Reference: TALBUTAL CIII (250 MG)(CAS DataBase Reference)
• NIST Chemistry Reference: TALBUTAL CIII (250 MG)(115-44-6)
• EPA Substance Registry System: TALBUTAL CIII (250 MG)(115-44-6)

Safety Data

• RIDADR: 3249
• HazardClass: 6.1(b)
• PackingGroup: III
• Hazardous Substances Data: 115-44-6(Hazardous Substances Data)

Usage

Description

TALBUTAL CIII (250 MG) is a structural isomer of Butalbital, a short to intermediate-acting barbiturate that acts as a nonselective depressant of the central nervous system (CNS). It is a white solid and is used as a sedative and hypnotic. TALBUTAL CIII (250 MG) is a controlled substance and is marketed under the brand name Lotusate by Sanofi Aventis.

Uses

Used in Pharmaceutical Industry:
TALBUTAL CIII (250 MG) is used as a sedative and hypnotic for the treatment of insomnia, anxiety, and other conditions that require the suppression of the central nervous system. Its short to intermediate-acting properties make it suitable for managing acute symptoms and promoting sleep.
Used in Medical Applications:
TALBUTAL CIII (250 MG) is used as a nonselective depressant of the central nervous system for the management of various medical conditions, such as seizures, migraines, and other neurological disorders. Its ability to depress the CNS makes it a valuable tool in the treatment of these conditions.
Used in Controlled Substances:
As a controlled substance, TALBUTAL CIII (250 MG) is used under strict regulations and guidelines to ensure its safe and effective use. Its controlled status helps to prevent misuse, abuse, and diversion, ensuring that it is only used for legitimate medical purposes.

InChI:InChI=1/C13H20N2O3/c1-6-8-13(9(3)7-2)10(16)14(4)12(18)15(5)11(13)17/h6,9H,1,7-8H2,2-5H3

Synthetic route

s-butyl bromide (78-76-2, 5787-31-5) + 5-allyl-pyrimidine-2,4,6-trione (2565-43-7) → talbutal (115-44-6)

Conditions	Yield
With sodium hydroxide

(+-)-allyl-sec-butyl-malonic acid diethyl ester → talbutal (115-44-6)

Conditions	Yield
With sodium ethanolate; urea

talbutal (115-44-6) → allyl-sec-butyl-malonic acid-monoureide

Conditions	Yield
With alkaline solution

talbutal (115-44-6) → Allyl-(1-methylpropyl)-acetamid (90949-61-4)

Conditions	Yield
With ammonia at 200℃;

Upstream product

• 78-76-2 s-butyl bromide 
• 2565-43-7 5-allyl-pyrimidine-2,4,6-trione