1150310-15-8 Usage
Description
(alphaE)-alpha-[(3,4-Dihydroxy-5-nitrophenyl)methylene]-beta-oxo-1-piperidinepropanenitrile is a chemical compound that is identified as an impurity in Entacapone (E558500). Entacapone is a medication that functions as a peripherally acting inhibitor of catechol-O-methyl transferase (COMT), an enzyme that plays a crucial role in the metabolism of catecholamine neurotransmitters and related drugs. (alphaE)-alpha-[(3,4-Dihydroxy-5-nitrophenyl)methylene]-beta-oxo-1-piperidinepropanenitrile is significant in the context of its association with antiparkinsonian treatments.
Uses
Used in Pharmaceutical Industry:
(alphaE)-alpha-[(3,4-Dihydroxy-5-nitrophenyl)methylene]-beta-oxo-1-piperidinepropanenitrile is used as an impurity in the production of Entacapone, which is an antiparkinsonian drug. The application reason for this compound lies in its connection to the medication's function, as it is a byproduct in the synthesis of Entacapone. Entacapone helps in the treatment of Parkinson's disease by extending the duration of action of dopamine, a neurotransmitter that is deficient in Parkinson's patients, thus providing relief from the symptoms of the disease.
Check Digit Verification of cas no
The CAS Registry Mumber 1150310-15-8 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,5,0,3,1 and 0 respectively; the second part has 2 digits, 1 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 1150310-15:
(9*1)+(8*1)+(7*5)+(6*0)+(5*3)+(4*1)+(3*0)+(2*1)+(1*5)=78
78 % 10 = 8
So 1150310-15-8 is a valid CAS Registry Number.
1150310-15-8Relevant articles and documents
FTO INHIBITORS
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, (2017/01/31)
The invention provides compounds that inhibit FTO (fat mass and obesity), including pharmaceutically acceptable salts, hydrides and stereoisomers thereof. The compounds are employed in pharmaceutical compositions, and methods of making and use, including treating a person in need thereof, particularly obesity, with an effective amount of the compound or composition, and detecting a resultant improvement in the person's health or condition.
The synthesis and biological evaluation of some caffeic acid amide derivatives: E-2-Cyano-(3-substituted phenyl)acrylamides
Zhou, Wei,Li, Hai-bo,Xia, Chun-nian,Zheng, Xian-ming,Hu, Wei-xiao
experimental part, p. 1861 - 1865 (2009/11/30)
A series of caffeic acid amide derivatives 2-cyano-(3-substituted phenyl)acrylamides were synthesized via Knoevenogal condensation of substituted benzaldehydes with cyanoacetamides. The structure of compound 1f was determined as E-isomer by X-ray diffractive analysis. The biological screening tests in vitro showed that compound 1b has obvious inhibitory activities against human gastric carcinoma cell line BGC-823, human nasopharyngeal carcinoma cell line KB and human hepatoma cell line BEL-7402 with IC50 values of 5.6 μg/mL, 13.1 μg/mL and 12.5 μg/mL, respectively. Some preliminary structure-activity relationships (SAR) were also proposed which may provide a direction for further study.
