1152032-90-0

Basic information

• Product Name: 2-allyl-3-(difluoro(phenylsulfanyl)methyl)-3-hydroxy-isoindolin-1-one
• Synonyms: 2-allyl-3-(difluoro(phenylsulfanyl)methyl)-3-hydroxy-isoindolin-1-one
• CAS NO: 1152032-90-0
• Molecular Weight: 347.385
• Mol File: 1152032-90-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-allyl-3-(difluoro(phenylsulfanyl)methyl)-3-hydroxy-isoindolin-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-allyl-3-(difluoro(phenylsulfanyl)methyl)-3-hydroxy-isoindolin-1-one(1152032-90-0)
• EPA Substance Registry System: 2-allyl-3-(difluoro(phenylsulfanyl)methyl)-3-hydroxy-isoindolin-1-one(1152032-90-0)

Safety Data

• Hazardous Substances Data: 1152032-90-0(Hazardous Substances Data)

Upstream product

• 5428-09-1 3-phthalimido-1-propene 
• 1535-67-7 difluoromethyl phenyl sulfide 
• 536975-49-2 phenyl (trimethylsilyl)difluoromethyl sulfide 

Relevant articles and documents

Nucleophilic gem-difluoro(phenylsulfanyl)methylation of carbonyl compounds with PhSCF2H in the presence of a phosphazene as a base

Direct nucleophilic gem-difluoro(phenylsulfanyl)methylation of carbonyl compounds has been achieved by use of difluoro(phenylsulfanyl)methane (PhSCF2H) and the phosphazene base P4-tBu in THF. Non-enolizable aldehydes and ketones are suitable substrates to undergo nucleophilic gem-difluoro(phenylsulfanyl)methylation, providing α-gem-difluoromethylated adducts in good yields. In addition, this methodology is also applicable with cyclic imides and acid anhydrides. Direct nucleophilic gem-difluoro(phenylsulfanyl)methylation of aromatic aldehydes and ketones, cyclic imides, and acid anhydrides with difluoro(phenylsulfanyl)methane (PhSCF2H) reagent was achieved in the presence of the phosphazene P4-tBu as a base. The corresponding adducts should be useful for further synthetic conversion into a variety of fluorinated compounds. Copyright