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115250-39-0

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  • D-epi-Inositol,3,4-dideoxy-4-[[2-hydroxy-1-(hydroxymethyl)ethyl]amino]-2-C-[(phenylmethoxy)methyl]-1,5,6-tris-O-(phenylmethyl)- 115250-39-0

    Cas No: 115250-39-0

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  • 1 Kilogram

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115250-39-0 Usage

Description

Tetrabenzyl-voglibose is a chemical derivative of Voglibose, an α-Glucosidase inhibitor. It is a compound that has been modified with four benzyl groups, which may enhance its properties or applications in various fields. The compound is known for its potential role in the management of diabetes and other related conditions.

Uses

Used in Pharmaceutical Industry:
Tetrabenzyl-voglibose is used as an antidiabetic agent for the treatment of diabetes mellitus. As a derivative of Voglibose, it functions as an α-Glucosidase inhibitor, which helps in slowing down the digestion of carbohydrates and reducing the spike in blood sugar levels after a meal. This makes it a valuable component in the development of medications for diabetes management.
Used in Research and Development:
In the field of research and development, Tetrabenzyl-voglibose may be utilized as a starting material or intermediate for the synthesis of other bioactive compounds. Its unique structure and properties can be explored for potential applications in drug discovery, particularly in the areas of metabolic disorders and related conditions.
Used in Drug Delivery Systems:
Similar to Gallotannin, Tetrabenzyl-voglibose could potentially be incorporated into novel drug delivery systems to enhance its bioavailability, delivery, and therapeutic outcomes. This may involve the use of various organic and metallic nanoparticles as carriers for the compound, aiming to improve its overall effectiveness in treating diabetes and other conditions.
Please note that the provided materials only mention the use of Tetrabenzyl-voglibose as an antidiabetic. The other potential uses mentioned above are speculative and based on the general properties and applications of similar compounds. Further research and development would be required to confirm these potential applications.

Check Digit Verification of cas no

The CAS Registry Mumber 115250-39-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,5,2,5 and 0 respectively; the second part has 2 digits, 3 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 115250-39:
(8*1)+(7*1)+(6*5)+(5*2)+(4*5)+(3*0)+(2*3)+(1*9)=90
90 % 10 = 0
So 115250-39-0 is a valid CAS Registry Number.
InChI:InChI=1/C38H45NO7/c40-22-33(23-41)39-34-21-38(42,28-43-24-29-13-5-1-6-14-29)37(46-27-32-19-11-4-12-20-32)36(45-26-31-17-9-3-10-18-31)35(34)44-25-30-15-7-2-8-16-30/h1-20,33-37,39-42H,21-28H2/t34?,35-,36?,37-,38-/m0/s1

115250-39-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-[[(2S,4S,5S)-5-hydroxy-2,3,4-tris(phenylmethoxy)-5-(phenylmethoxymethyl)cyclohexyl]amino]propane-1,3-diol

1.2 Other means of identification

Product number -
Other names Tetrabenzyl Voglibose

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:115250-39-0 SDS

115250-39-0Synthetic route

(1S)-(1(OH),2,4/1,3)-2,3,4-Tri-O-benzyl-1-C-<(benzyloxy)methyl>-5-oxo-1,2,3,4-cyclohexanetetrol
115250-38-9

(1S)-(1(OH),2,4/1,3)-2,3,4-Tri-O-benzyl-1-C-<(benzyloxy)methyl>-5-oxo-1,2,3,4-cyclohexanetetrol

serinol
534-03-2

serinol

(1S)-(1(OH),2,4,5/1,3)-2,3,4-tri-O-benzyl-5-<<2-hydroxy-1-(hydroxymethyl)ethyl>amino>-1-C-<(benzyloxy)methyl>-1,2,3,4-cyclohexanetetrol
115250-39-0

(1S)-(1(OH),2,4,5/1,3)-2,3,4-tri-O-benzyl-5-<<2-hydroxy-1-(hydroxymethyl)ethyl>amino>-1-C-<(benzyloxy)methyl>-1,2,3,4-cyclohexanetetrol

Conditions
ConditionsYield
With sodium cyanoborohydride In methanol for 16h; Ambient temperature;75%
tetra-O-benzylvaliolamine
140926-94-9

tetra-O-benzylvaliolamine

serinol
534-03-2

serinol

(1S)-(1(OH),2,4,5/1,3)-2,3,4-tri-O-benzyl-5-<<2-hydroxy-1-(hydroxymethyl)ethyl>amino>-1-C-<(benzyloxy)methyl>-1,2,3,4-cyclohexanetetrol
115250-39-0

(1S)-(1(OH),2,4,5/1,3)-2,3,4-tri-O-benzyl-5-<<2-hydroxy-1-(hydroxymethyl)ethyl>amino>-1-C-<(benzyloxy)methyl>-1,2,3,4-cyclohexanetetrol

Conditions
ConditionsYield
Stage #1: tetra-O-benzylvaliolamine; serinol In methanol at 20℃; for 1h;
Stage #2: With sodium cyanoborohydride In methanol
Stage #3: With hydrogenchloride In methanol; water pH=8.0;
dihydroxyacetone
96-26-4

dihydroxyacetone

tetra-O-benzylvaliolamine
140926-94-9

tetra-O-benzylvaliolamine

(1S)-(1(OH),2,4,5/1,3)-2,3,4-tri-O-benzyl-5-<<2-hydroxy-1-(hydroxymethyl)ethyl>amino>-1-C-<(benzyloxy)methyl>-1,2,3,4-cyclohexanetetrol
115250-39-0

(1S)-(1(OH),2,4,5/1,3)-2,3,4-tri-O-benzyl-5-<<2-hydroxy-1-(hydroxymethyl)ethyl>amino>-1-C-<(benzyloxy)methyl>-1,2,3,4-cyclohexanetetrol

Conditions
ConditionsYield
Stage #1: dihydroxyacetone; tetra-O-benzylvaliolamine In methanol at 20 - 30℃; for 0.5 - 1h;
Stage #2: With hydrogenchloride; sodium cyanoborohydride In methanol; water pH=~ 6.0; Product distribution / selectivity;
(1S)-(1(OH),2,4,5/1,3)-2,3,4-tri-O-benzyl-5-<<2-hydroxy-1-(hydroxymethyl)ethyl>amino>-1-C-<(benzyloxy)methyl>-1,2,3,4-cyclohexanetetrol
115250-39-0

(1S)-(1(OH),2,4,5/1,3)-2,3,4-tri-O-benzyl-5-<<2-hydroxy-1-(hydroxymethyl)ethyl>amino>-1-C-<(benzyloxy)methyl>-1,2,3,4-cyclohexanetetrol

voglibose
83480-29-9

voglibose

Conditions
ConditionsYield
With formic acid; palladium In methanol Ambient temperature;94%
With boron trifluoride diethyl etherate; diisopropylamine In tetrahydrofuran at 15 - 30℃; Reagent/catalyst; Solvent;82.86%
With hydrogenchloride; hydrogen; palladium 10% on activated carbon In tetrahydrofuran; methanol; water at 20℃; under 2206.72 - 2574.5 Torr; for 3h;
(1S)-(1(OH),2,4,5/1,3)-2,3,4-tri-O-benzyl-5-<<2-hydroxy-1-(hydroxymethyl)ethyl>amino>-1-C-<(benzyloxy)methyl>-1,2,3,4-cyclohexanetetrol
115250-39-0

(1S)-(1(OH),2,4,5/1,3)-2,3,4-tri-O-benzyl-5-<<2-hydroxy-1-(hydroxymethyl)ethyl>amino>-1-C-<(benzyloxy)methyl>-1,2,3,4-cyclohexanetetrol

A

4-benzyl-voglibose

4-benzyl-voglibose

B

voglibose
83480-29-9

voglibose

Conditions
ConditionsYield
With formic acid; palladium on activated charcoal In methanol; water Inert atmosphere;A 0.7 g
B 16 g

115250-39-0Downstream Products

115250-39-0Relevant articles and documents

Synthesis method of voglibose

-

Paragraph 0060; 0061; 0093-0095, (2021/08/07)

The invention provides a synthesis method of voglibose, and solves the technical problems that in an existing synthesis method of voglibose, raw materials are difficult to obtain, high in price, large in investment, low in yield and not suitable for industrial production. The synthesis method comprises the steps: synthesizing a compound V by taking glucose monohydrate and sodium acetate as raw materials through eleven reaction steps; and preparing a compound VIII from the compound V through an addition reaction, a ring-opening reaction and an aldol condensation reaction, and thus obtaining voglibose through amination reduction of the compound VIII. The synthesis method of voglibose can be widely applied to the technical field of voglibose synthesis methods.

Synthesis of valiolamine and its N-substituted derivatives AO-128, validoxylamine G, and validamycin G via branched-chain inosose derivatives

Fukase,Horii

, p. 3651 - 3658 (2007/10/02)

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