1152550-37-2Relevant articles and documents
Identification and optimisation of a series of tetrahydrobenzotriazoles as metabotropic glutamate receptor 5-selective positive allosteric modulators that improve performance in a preclinical model of cognition
Ellard, John M.,Madin, Andrew,Philps, Oliver,Hopkin, Mark,Henderson, Scott,Birch, Louise,O'Connor, Desmond,Arai, Tohru,Takase, Kazuma,Morgan, Louise,Reynolds, David,Talma, Sonia,Howley, Eimear,Powney, Ben,Payne, Andrew H.,Hall, Adrian,Gartlon, Jane E.,Dawson, Lee A.,Castro, Luis,Atkinson, Peter J.
, p. 5792 - 5796 (2015)
Herein we describe a series of tetrahydrobenzotriazoles as novel, potent metabotropic glutamate receptor subtype 5 (mGlu5) positive allosteric modulators (PAMs). Exploration of the SAR surrounding the tetrahydrobenzotriazole core ultimately led to the ide
BENZIMIDAZOLE INHIBITORS OF LEUKOTRIENE PRODUCTION
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Page/Page column 44, (2012/05/19)
The present invention relates to compounds of formula IA and IB and pharmaceutically acceptable salts thereof, wherein R1-R7 are as defined herein. The invention also relates to pharmaceutical compositions comprising these compounds,