1152570-61-0

Basic information

• Product Name: C₁₂H₁₀ClFN₂
• Synonyms: C₁₂H₁₀ClFN₂
• CAS NO: 1152570-61-0
• Molecular Weight: 236.676
• Mol File: 1152570-61-0.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: C₁₂H₁₀ClFN₂(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₂H₁₀ClFN₂(1152570-61-0)
• EPA Substance Registry System: C₁₂H₁₀ClFN₂(1152570-61-0)

Safety Data

• Hazardous Substances Data: 1152570-61-0(Hazardous Substances Data)

Upstream product

• 345-17-5 1-chloro-4-fluoro-2-nitrobenzene 
• 106-47-8 4-chloro-aniline 
• 364-74-9 1,4-difluoro-2-nitrobenzene 
• 79445-97-9 2-(4-chloroanilino)-5-fluoronitrobenzene 

Relevant articles and documents

Synthesis and biological evaluation of novel pyrazole carboxamide with diarylamine-modi?ed scaffold as potent antifungal agents

Twenty-seven novel pyrazole carboxamides with diarylamine-modi?ed scaffold were designed, synthesized and characterized in detail via 1H NMR, 13C NMR, IR and ESI-HRMS. Preliminary bioassays showed that some of the target compounds exhibited good antifungal activity against Rhizoctonia solani, Rhizoctonia cerealis and Sclerotinia sclerotiorum. Among them, compound 9c-7 exhibited the highest antifungal activities against R. solani, R. cerealis and S. sclerotiorum in vitro with IC50 values of 0.013, 1.608 and 1.874?μg/mL, respectively. Notably, compound 9c-7 still presented the highest fungicidal activities against R. solani in vivo with an IC50 value of 22.21?μg/mL. Molecular docking simulation results reveal that compound 9c-7 binds well to the hydrophobic pockets of the receptor protein succinate dehydrogenase. This study suggests that compound 9c-7 could act as a potential fungicide to be used for further optimization.