115395-12-5Relevant articles and documents
Enantioselective reduction of β-keto amides by the fungus Mortierella isabellina
Quiros, Margarita,Rebolledo, Francisca,Liz, Ramon,Gotor, Vicente
, p. 3035 - 3038 (1997)
Incubations of the fungus Mortierella isabellina NRRL 1757 with 3-oxo-3-phenylpropanamide, 3-oxobutanamide and with some of their N-alkyl derivatives afford the corresponding (S)-3-hydroxyamides usually in high chemical yields and enantiomeric excesses.
Synthesis of α-Alkyl-β-Hydroxy Amides through Biocatalytic Dynamic Kinetic Resolution Employing Alcohol Dehydrogenases
Méndez-Sánchez, Daniel,Mourelle-Insua, ángela,Gotor-Fernández, Vicente,Lavandera, Iván
supporting information, p. 2706 - 2712 (2019/05/10)
Chiral (α-substituted) β-hydroxy amides are interesting derivatives as they are useful building blocks of many biologically active compounds. Herein, the biocatalytic stereocontrolled synthesis of various acyclic syn-α-alkyl-β-hydroxy amides through a dynamic kinetic resolution is shown. Hence, a series of overexpressed alcohol dehydrogenases (ADHs) in Escherichia coli was used to reduce the corresponding racemic β-keto amides. Among them, ADH-A from Rhodococcus ruber and commercial evo-1.1.200 afforded the best activities and selectivities, giving access to the opposite enantiomers with high diastereomeric excess and excellent enantiomeric excess. Some of these compounds were obtained at semipreparative scale. (Figure presented.).
Synthesis of 1,3-Dioxin-4-Ones and their use in synthesis.(1)) XVIII. Synthesis of azetidin-2-ones from 1,3-Dioxin-4-ones via 3-Hydroxycarboxamides
Sakaki,Kobayashi,Sato,Kaneko
, p. 2952 - 2960 (2007/10/02)
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