115416-38-1 Usage
Description
5-(Biotinamido)pentylamine is a light brown solid that serves as a versatile reagent in the preparation of various biotin derivatives. It is an amine and sulfhydryl reactive biotinylation reagent, which allows for the attachment of biotin to molecules containing these functional groups.
Uses
Used in Biochemistry Research:
5-(Biotinamido)pentylamine is used as a reagent for the preparation of biotin derivatives, which are essential in various biochemical research applications. These biotin derivatives can be used for the detection, quantification, and manipulation of biomolecules in laboratory settings.
Used in Iodoacetyl LC Biotin:
5-(Biotinamido)pentylamine is used as an amine and sulfhydryl reactive biotinylation reagent for the synthesis of iodoacetyl LC biotin. 5-(Biotinamido)pentylamine is particularly useful in the labeling and detection of biomolecules, such as proteins and nucleic acids, in various analytical techniques, including liquid chromatography and mass spectrometry.
Used in Drug Delivery Systems:
In the pharmaceutical industry, 5-(Biotinamido)pentylamine can be used as a component in the development of drug delivery systems. Its ability to react with amine and sulfhydryl groups allows for the attachment of biotin to drug molecules, enabling targeted delivery and enhanced therapeutic effects.
Used in Diagnostic Assays:
5-(Biotinamido)pentylamine is used as a key component in the development of diagnostic assays, particularly in the field of immunoassays. The biotin-streptavidin interaction provides a highly specific and sensitive detection mechanism for various analytes, such as antibodies, antigens, and other biomolecules.
Used in Biosensor Development:
In the field of biosensors, 5-(Biotinamido)pentylamine can be utilized as a component in the fabrication of biotinylated probes. These probes can be immobilized on sensor surfaces and used for the detection of specific biomolecules, such as DNA, RNA, or proteins, in a wide range of applications, including environmental monitoring, medical diagnostics, and food safety testing.
Check Digit Verification of cas no
The CAS Registry Mumber 115416-38-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,5,4,1 and 6 respectively; the second part has 2 digits, 3 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 115416-38:
(8*1)+(7*1)+(6*5)+(5*4)+(4*1)+(3*6)+(2*3)+(1*8)=101
101 % 10 = 1
So 115416-38-1 is a valid CAS Registry Number.
InChI:InChI=1/C15H28N4O2S/c16-8-4-1-5-9-17-13(20)7-3-2-6-12-14-11(10-22-12)18-15(21)19-14/h11-12,14H,1-10,16H2,(H,17,20)(H2,18,19,21)/t11-,12-,14-/m0/s1
115416-38-1Relevant articles and documents
Design, synthesis, antitumor activities and biological studies of novel diaryl substituted fused heterocycles as dual ligands targeting tubulin and katanin
Gao, Feng,Liang, Yuru,Zhou, Pengfei,Cheng, Jiayi,Ding, Kuiling,Wang, Yang
, p. 177 - 194 (2019)
Microtubule is one of the important targets for cancer treatment. A novel class of diaryl substituted imidazo[4,5-c]pyridin-2-ones and imidazo[4,5-c]pyridines were designed based on combination principles by merging the structures of β-lactams and purine-type compounds known as tubulin polymerization inhibitor and katanin activity up-regulator, respectively. Their antitumor activities were evaluated in vitro and the mechanism was elucidated, leading to the identification of 1,6-diaryl-1H-imidazo[4,5-c]pyridin-2(3H)-one 20b as the first bifunctional agent that can target both tubulin and katanin simultaneously. The in vivo assays verified that compound 20b significantly inhibited xenograft tumor growth with good pharmacokinetic characteristics, demonstrating a promising potential for further development into anti-tumor drug candidates with a unique mechanism of dual-targeting microtubule.
PHOTOPROXIMITY PROFILING OF PROTEIN-PROTEIN INTERACTIONS IN CELLS
-
, (2021/04/01)
Photoactive probes and probe systems for detecting biological interactions are described. The photoactive probes include probes that combine both photocleavable and photoreactive moieties. The photoactive probe systems can include a first probe comprising a photocatalytic group and a second probe comprising a group that can act as a substrate for the reaction catalyzed by the photocatalytic group. The probes and probe systems can also include groups that can specifically bind to a binding partner on a biological entity of interest and a detectable group or a precursor thereof. The probes and probe systems can detect spatiotemporal interactions of proteins or cells. In some embodiments, the interactions can be detected in live cells. Also described are methods of detecting the biological interactions.
NOVEL MOLECULAR PROBES
-
Page/Page column 16, (2008/06/13)
The present invention relates to novel molecular probes having the formula (I) (I) useful for the characterization, detection, localization and isolation of the γ-secretase enzyme.