115459-50-2

Basic information

• Product Name: 2,3,5-Tri-O-benzoyl-D-ribofuranose
• Synonyms: 2,3,5-Tri-O-benzoyl-D-ribofuranose
• CAS NO: 115459-50-2
• Molecular Weight: 462.456
• Mol File: 115459-50-2.mol
• Article Data: 11

Chemical Properties

• CAS DataBase Reference: 2,3,5-Tri-O-benzoyl-D-ribofuranose(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3,5-Tri-O-benzoyl-D-ribofuranose(115459-50-2)
• EPA Substance Registry System: 2,3,5-Tri-O-benzoyl-D-ribofuranose(115459-50-2)

Safety Data

• Hazardous Substances Data: 115459-50-2(Hazardous Substances Data)

Upstream product

• 69350-76-1 methyl 2,3,5-tri-O-benzoyl-αβ-D-ribofuranoside 
• 14215-97-5 1-O-acetyl-2,3,5-tri-O-benzoyl-D-ribofuranose 
• 5991-01-5 2,3,5-(tri-O-benzoyl)-D-ribofuranosyl chloride 
• 22224-38-0 1,2,3,5-tetra-O-benzoyl-β-D-ribofuranose 
• 6974-32-9 1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose 
• 75-36-5 acetyl chloride 
• 16205-60-0 2,3,5-tri-O-benzoyl-β-D-ribofuranosyl bromide 

Downstream Products

• 3180-76-5 2',3',5'-tri-O-benzoyluridine 
• 1015447-26-3 2,3,5-tri-O-benzoyl-1-O-acetyl-β-4-thio-D-ribofuranose 
• 22860-91-9 2,3,5-tri-O-benzoyl-D-ribofuranosyl bromide 
• 51587-72-5 3'-Desoxyribostamycin 
• 16205-59-7 2,3,5-tri-O-benzoyl-1-bromo-α-D-erythro-pentofuranose 
• 457067-55-9 phenyl 2,3,5-tri-O-benzoyl-1-thio-β-D-ribofuranoside 

Relevant articles and documents

A Stereocontrolled Synthesis of 1,3,6-Tri-O-benzoyl-α-D-ribofuranose

The synthesis of a valuable carbohydrate intermediate, 1,3,5-tri-O-benzoyl-α-D-ribofuranose (4), has been achieved in a convenient, one-step process from commercially available 1-O-acetyl-2,3,5-tri-O-benzoyl-β-D-ribofuranose (7).

Effects of 5-O-Ribosylation of Aminoglycosides on Antimicrobial Activity and Selective Perturbation of Bacterial Translation

We studied six pairs of aminoglycosides and their corresponding ribosylated derivatives synthesized by attaching a β-O-linked ribofuranose to the 5-OH of the deoxystreptamine ring of the parent pseudo-oligosaccharide antibiotic. Ribosylation of the 4,6-disubstituted 2-deoxystreptamine aminoglycoside kanamycin B led to improved selectivity for inhibition of prokaryotic relative to cytosolic eukaryotic in vitro translation. For the pseudodisaccharide aminoglycoside scaffolds neamine and nebramine, ribosylated derivatives were both more potent antimicrobials and more selective to inhibition of prokaryotic translation. On the basis of the results of this study, we suggest that modification of the 5-OH position of the streptamine ring of other natural or semisynthetic pseudodisaccharide aminoglycoside scaffolds containing an equatorial amine at the 2′ sugar position with a β-O-linked ribofuranose is a promising avenue for the development of novel aminoglycoside antibiotics with improved efficacy and reduced toxicity.

2'-FLUORO-4'-SUBSTITUTED NUCLEOSIDES, THE PREPARATION AND USE

The present invention provides 2'-fluorine-4'-substituted-nucleoside analogues or their pro-drugs or 5'-phosphate esters (including the pro-drugs of the 5'-phosphate esters), preparation methods and uses thereof. The compounds have the general formula as follows: wherein: R = CH3, CH, N3, C≡CH; R' = H, F; X = F, OH, NH2; Y = H, CH3, F, OH, NH2 The compounds are used in the synthesis of drugs for the treatment of virus infection, especially for the treatment of HBV, HCV or HIV infection.