115483-66-4

Basic information

• Product Name: 2-(2,2-Diethoxyethylthio)benzamid
• CAS NO: 115483-66-4
• Molecular Weight: 269.365
• Mol File: 115483-66-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(2,2-Diethoxyethylthio)benzamid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2,2-Diethoxyethylthio)benzamid(115483-66-4)
• EPA Substance Registry System: 2-(2,2-Diethoxyethylthio)benzamid(115483-66-4)

Safety Data

• Hazardous Substances Data: 115483-66-4(Hazardous Substances Data)

Upstream product

• 2527-57-3 2,2'-dithiobisbenzamide 
• 2032-35-1 Bromoacetaldehyde diethyl acetal 

Downstream Products

• 23724-93-8 1-Methoxyisochinolin 

Relevant articles and documents

Heterocyclic Seven-Membered Ring Compounds, XXXIII. - Synthesis and Properties of 5-Methoxy-1,4-benzothiazepine and of 5-Methoxy-1-methyl-1,4-benzothiazepinium Tetrafluoroborate

Acid-catalyzed cyclisation of the amide acetal 2 yields the seven-membered ring lactam 3 which could be N-methylated to give compound 4 by treatment with sodium hydride/methyl iodide.On reaction with trimethyloxonium tetrafluoroborate, 3 was O-alkylated to yield the title thiazepine 5, the thermal stability of which is compared with that of the isomeric 4-methoxy-1,5-benzothiazepine C.Compound 5 could be oxidized to give the sulfone 6; thermolysis of 5 leads to sulfur and 1-methoxyisoquinoline (8).Alkylation of 5 with methyl iodide/silver tetrafluoroborate yields the sulfonium salt 7 which rearranges to 1-methoxy-4-(methylthio)isoquinoline (9) on heating in acetonitrile.