115500-88-4

Basic information

• Product Name: 2(S)-benzyloxycarbonylamino-5-keto-6-t-butyloxycarbonyl-7-phenyl heptanoic acid benzylester
• CAS NO: 115500-88-4
• Molecular Weight: 559.659
• Mol File: 115500-88-4.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2(S)-benzyloxycarbonylamino-5-keto-6-t-butyloxycarbonyl-7-phenyl heptanoic acid benzylester(CAS DataBase Reference)
• NIST Chemistry Reference: 2(S)-benzyloxycarbonylamino-5-keto-6-t-butyloxycarbonyl-7-phenyl heptanoic acid benzylester(115500-88-4)
• EPA Substance Registry System: 2(S)-benzyloxycarbonylamino-5-keto-6-t-butyloxycarbonyl-7-phenyl heptanoic acid benzylester(115500-88-4)

Safety Data

• Hazardous Substances Data: 115500-88-4(Hazardous Substances Data)

Upstream product

• 16537-10-3 tert-butyl 3-phenylpropanoate 
• 71389-33-8 Z-L-pGlu-OBzl 

Relevant articles and documents

Amino acid derivatives, their production and use in preparing carbapenem and carbapenam compounds

Novel amino acid derivatives of the formula STR1 wherein R1 is a protecting group removable under reducing or acid conditions, and R2 and R5 are hydrogen or carboxylic protecting groups, are useful as intermediates in preparing stereospecific carbapenam/carbapenem derivatives. R1 is removed under reducing conditions to form a pyrrolidine derivative, which is further cyclized from the R5 =H compound to form a β-lactam ring. Stereospecificity at the 6-position is achieved by treatment with lithium diisopropylamide (LDA) and quenching at different termperatures. Compound (I) can be prepared by treating R1 -protected R3 -pyrrolidone carboxylic acid R2 -ester with a lithium enolate of the formula R4 CHLiCO2 R5. The lithium enolate can be formed from R4 CH2 CO2 R5 by treatment with LDA.