1155224-44-4

Basic information

• Product Name: 8-[3-(2-diethylaminoethoxy)phenyl]-1,3-dimethylxanthine
• CAS NO: 1155224-44-4
• Molecular Weight: 371.439
• Mol File: 1155224-44-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 8-[3-(2-diethylaminoethoxy)phenyl]-1,3-dimethylxanthine(CAS DataBase Reference)
• NIST Chemistry Reference: 8-[3-(2-diethylaminoethoxy)phenyl]-1,3-dimethylxanthine(1155224-44-4)
• EPA Substance Registry System: 8-[3-(2-diethylaminoethoxy)phenyl]-1,3-dimethylxanthine(1155224-44-4)

Safety Data

• Hazardous Substances Data: 1155224-44-4(Hazardous Substances Data)

Upstream product

• 1155224-39-7 6-amino-5-[{3-(2-diethylaminoethoxy)benzylidene}amino]-1,3-dimethyluracil 

Relevant articles and documents

Synthesis of a series of 8-(substituted-phenyl)xanthines and a study on the effects of substitution pattern of phenyl substituents on affinity for adenosine A1 and A2A receptors

A new series of 8-(substituted-phenyl)xanthines have been synthesized and compounds were evaluated for their affinity for A1 and A2 adenosine receptors (AR) using radioligand binding assays. The effects of varying the positions of 8-phenyl substituents on affinity and selectivity at A1 and A2A adenosine receptors have been studied. Isovanilloid 1,3-dimethyl-8-[4-methoxy-3-(2-morpholin-4-ylethoxy)phenylxanthine (9d) displayed the highest affinity and selectivity towards A2A AR subtypes with Ki = 100 nM over A1 receptors (Ki > 100 mM). It has been observed that substitution pattern on 8-phenyl group greatly affects the affinity and selectivity at adenosine receptors, with A2A tolerating bulkier substituents than did A1 receptors.