115538-83-5 Usage
Description
2-[4-(3-CHLORO-2-HYDROXYPROPOXY)PHENYL]ACETAMIDE is a chemical compound with the molecular structure characterized by a phenyl group connected to a chloro-hydroxypropoxy side chain and an acetamide group. It is an impurity found in Atenolol, a cardioselective β-adrenergic blocker used in the treatment of various cardiovascular conditions.
Uses
Used in Pharmaceutical Industry:
2-[4-(3-CHLORO-2-HYDROXYPROPOXY)PHENYL]ACETAMIDE is used as an impurity in the manufacturing process of Atenolol (A790075), a cardioselective β-adrenergic blocker. Its presence is significant as it can affect the purity and efficacy of the final pharmaceutical product. The compound is essential for quality control and assurance in the production of Atenolol, ensuring the safety and effectiveness of the medication for patients with cardiovascular conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 115538-83-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,5,5,3 and 8 respectively; the second part has 2 digits, 8 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 115538-83:
(8*1)+(7*1)+(6*5)+(5*5)+(4*3)+(3*8)+(2*8)+(1*3)=125
125 % 10 = 5
So 115538-83-5 is a valid CAS Registry Number.
115538-83-5Relevant articles and documents
Highly enantioselective CALB-catalyzed kinetic resolution of building blocks for β-blocker atenolol
Lund, Ingvild T.,B?ckmann, P?l L.,Jacobsen, Elisabeth E.
, p. 7288 - 7292 (2016)
Both enantiomers of 4-(3-chloro-2-hydroxypropoxy)phenyl)acetamide has been synthesized in 98.5–99% enantiomeric excess by use of lipase B from Candida antarctica as catalyst. The R-alcohol is a building block for the cardioselective β-blocker (S)-atenolol ((S)-2-(4-(2-hydroxy-3-(isopropylamino)propoxy)phenyl)acetamide. Performing kinetic resolutions of 3-chloro-1-phenoxy-2-propanol and 3-bromo-1-phenoxy-2-propanol with vinyl butanoate as acyl donor and the same CALB enzyme, but a different preparation, showed higher E-values than previously reported.
Lipase catalysis in organic solvents. Application to the synthesis of (R)- and (S)-atenolol
Bevinakatti,Banerji
, p. 6003 - 6005 (2007/10/02)
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