115661-82-0 Usage
Description
7-Indolinecarbonitrile, also known as 7-cyanoindoline, is an organic compound with the molecular formula C8H6N2. It is a white crystalline solid and is an important intermediate in the synthesis of various pharmaceuticals and organic compounds. It possesses a nitrile group (-CN) and an indoline ring, which contribute to its reactivity and utility in chemical reactions.
Uses
Used in Pharmaceutical Industry:
7-Indolinecarbonitrile is used as a reactant for the preparation of silodosin (S465000), an α1a-adrenoceptor antagonist. It plays a crucial role in the treatment of benign prostatic hyperplasia (BPH), a common condition in aging men that causes enlarged prostate and urinary problems. The compound's reactivity and structural features make it a valuable building block in the development of new drugs targeting this medical condition.
Check Digit Verification of cas no
The CAS Registry Mumber 115661-82-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,5,6,6 and 1 respectively; the second part has 2 digits, 8 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 115661-82:
(8*1)+(7*1)+(6*5)+(5*6)+(4*6)+(3*1)+(2*8)+(1*2)=120
120 % 10 = 0
So 115661-82-0 is a valid CAS Registry Number.
InChI:InChI=1/C9H8N2/c10-6-8-3-1-2-7-4-5-11-9(7)8/h1-3,11H,4-5H2
115661-82-0Relevant articles and documents
PROCESS FOR THE PREPARATION OF SILODOSIN
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Page/Page column 27; 28, (2021/10/15)
The present invention relates to a new process of preparation of Silodosin, or a pharmaceutically acceptable salt thereof. Another aspect of the invention concerns compounds of formula II: or their pharmaceutically acceptable salts thereof, and their use for the preparation of Silodosin or a pharmaceutically acceptable salt thereof.
Process for ortho-cyanation of phenols or phenylamines
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, (2008/06/13)
A process for ortho-cyanation of phenols or phenylamines which comprises reacting a phenyl compound having hydroxy or optionally substituted amino or cyclic amino, of which ortho position is vacant, with trichloroacetonitrile, C1 -C5 alkyl thiocyanate or C6 -C12 aryl thiocyanate in the presence of a boron trihalide and treating the resultant product with an alkali is provided, and said process is useful in the synthesis of intermediates for medicinals or pesticides.