115787-53-6

Basic information

• Product Name: 5-<<(1,1-Dimethylethyl)amino>acetyl>-2-hydroxybenzaldehyde hydrochloride
• Synonyms: 5-<<(1,1-Dimethylethyl)amino>acetyl>-2-hydroxybenzaldehyde hydrochloride
• CAS NO: 115787-53-6
• Molecular Weight: 271.744
• Mol File: 115787-53-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 5-<<(1,1-Dimethylethyl)amino>acetyl>-2-hydroxybenzaldehyde hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 5-<<(1,1-Dimethylethyl)amino>acetyl>-2-hydroxybenzaldehyde hydrochloride(115787-53-6)
• EPA Substance Registry System: 5-<<(1,1-Dimethylethyl)amino>acetyl>-2-hydroxybenzaldehyde hydrochloride(115787-53-6)

Safety Data

• Hazardous Substances Data: 115787-53-6(Hazardous Substances Data)

Upstream product

• 90-02-8 salicylaldehyde 
• 115787-50-3 5-(2-bromoacetyl)-2-hydroxybenzaldehyde 
• 75-64-9 tert-butylamine 
• 115787-56-9 2-Bromo-1-<3-<<(1,1-dimethylethyl)imino>methyl>-4-hydroxyphenyl>ethanone 
• 115787-57-0 2-Chloro-1-<3-<<(1,1-dimethylethyl)imino>methyl>-4-hydroxyphenyl>ethanone 
• 115787-51-4 5-(Chloroacetyl)-2-hydroxybenzaldehyde 

Downstream Products

• 34391-04-3 Levalbuterol 
• 18559-94-9 Salbutamol 
• 115787-52-5 5-(2-tert-Butylamino-acetyl)-2-hydroxy-benzaldehyde 

Relevant articles and documents

(R)- albuterol hydrochloride asymmetric preparation method (by machine translation)

The present invention relates to a high-efficient chiral catalyst synthesis of (R)- albuterol hydrochloride the asymmetric synthesis of the new method, the synthesis step includes: 1) salicylaldehyde with a halo of acetyl halogen crafts acylation reaction halo; 2) obtained after the the halogenated ketone uses unclebutylamine amine solution obtained after hydrolysis to the protection of the salicylaldehyde aminoketone; 3) this aminoketone in chiral amino alcohol derivative of the chiral borane the presence of a catalyst, is reduced to (R)- albuterol crude product, then the purified hydrochloric salt to obtain the high purity of the (R)- albuterol hydrochloride. (by machine translation)

A short synthesis of albuterol

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