1157938-97-0 Usage
Description
Ethanone, 1-(2,5-difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)1-(2,5-Difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanone,1-(2,5-difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanone is an organic compound that belongs to the class of triazole antifungal agents. It is structurally related to Isavuconazole (I777830), a well-known antifungal drug. Ethanone, 1-(2,5-difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)1-(2,5-Difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanone,1-(2,5-difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanone exhibits potent antifungal properties and is characterized by its unique molecular structure, which includes a 2,5-difluorophenyl group and a 1,2,4-triazol-1-yl group attached to the ethanone backbone.
Uses
Used in Pharmaceutical Industry:
Ethanone, 1-(2,5-difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)1-(2,5-Difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanone,1-(2,5-difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanone is used as an antifungal agent for the treatment of various fungal infections. Its application in this industry is due to its potent antifungal activity, which makes it a valuable compound for the development of new antifungal drugs.
Used in Research and Development:
In the field of research and development, this compound serves as a valuable tool for studying the structure-activity relationships of triazole antifungal agents. Its unique molecular structure allows researchers to investigate the role of specific functional groups in the antifungal activity of these compounds, potentially leading to the discovery of more effective and targeted antifungal drugs.
Used in Drug Synthesis:
Ethanone, 1-(2,5-difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)1-(2,5-Difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanone,1-(2,5-difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanone can be used as a key intermediate in the synthesis of novel antifungal drugs. Its unique structural features make it an attractive candidate for the development of new drugs with improved potency, selectivity, and reduced side effects.
Check Digit Verification of cas no
The CAS Registry Mumber 1157938-97-0 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,1,5,7,9,3 and 8 respectively; the second part has 2 digits, 9 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1157938-97:
(9*1)+(8*1)+(7*5)+(6*7)+(5*9)+(4*3)+(3*8)+(2*9)+(1*7)=200
200 % 10 = 0
So 1157938-97-0 is a valid CAS Registry Number.
1157938-97-0Relevant articles and documents
Preparation method of isavuconazole and isavuconazole prepared through method
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Paragraph 0019; 0023, (2016/10/10)
The invention relates to a preparation method of isavuconazole and isavuconazole prepared through the method.The preparation method comprises the following steps that 1, diflurophenyl acetylchloride, triazole, CuI, potassium carbonate and first organic solvent are sequentially added into a reaction kettle, reacting under stirring is performed at the temperature of 80 DEG C-100 DEG C, and then purifying is performed to obtain a first product; 2, propionitrile, a catalyst and second organic solvent are added into a reaction container, the temperature is lowered to minus 20 DEG C-minus 5 DEG C, the second organic solvent containing the first product is dropwise added, reacting and purifying are performed to obtain a second product, and a mixture composed of C-9 primary amine quinine and copper pigment alkali is adopted as the catalyst; 3, the second product is added into another reaction container, diethylphosphorodithioate, water and mixed isopropanol solvent are added into the reaction container, heating is performed until the temperature is increased to 80 DEG C-90 DEG C, reacting under stirring and purifying are sequentially performed, and a third product is obtained; 4, the third product, 2-bromo-4'-acetylbenzonitrile and third organic solvent are mixed, react under stirring at the temperature of 60 DEG C-70 DEG C and then purified, and the isavuconazole is obtained.Accordingly, a novel synthetic route is redesigned, and the reaction steps are reduced.