1158170-79-6

Basic information

• Product Name: lidocainium ibuprofenate
• Synonyms: lidocainium ibuprofenate
• CAS NO: 1158170-79-6
• Molecular Weight: 440.626
• Mol File: 1158170-79-6.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: lidocainium ibuprofenate(CAS DataBase Reference)
• NIST Chemistry Reference: lidocainium ibuprofenate(1158170-79-6)
• EPA Substance Registry System: lidocainium ibuprofenate(1158170-79-6)

Safety Data

• Hazardous Substances Data: 1158170-79-6(Hazardous Substances Data)

Upstream product

• 73-78-9 lidocaine hydrochloride 
• 31121-93-4 sodium 2-(4-isobutylphenyl)propionate 
• 15687-27-1 ibuprofen 
• 137-58-6 2-diethylamino-N-(2,6-dimethylphenyl)-acetamide 

Relevant articles and documents

Improved transdermal permeability of ibuprofen by ionic liquid technology: Correlation between counterion structure and the physicochemical and biological properties

The aim of this study was to explore the feasibility of transdermal delivery of ibuprofen using ionic liquid technology. Ibuprofen, a non-steroidal anti-inflammatory drug, was transformed into nine ionic liquids using aromatic, tetraalkylammonium and tetr

Thermal and oxidative decomposition of ibuprofen-based ionic liquids

Pharmaceuticals are often discharged into the environment and later detected in drinking water, plants, and soil. Thus, the decomposition or biodegradability of these compounds is a constant concern. The objective of this work was to show the decomposition of pharmaceutical ionic liquids (IL-APIs) via thermal and oxidative methods. Long- and short-term thermal decomposition and oxidative processes in the presence and absence of H2O2 and UV-C irradiation were investigated for four IL-APIs derived from ibuprofen. The results of short-term thermal stability experiments showed that the IL-APIs were thermally stable up to 160–200 °C, and have an activation energy of 60–100 kJ mol?1 for decomposition, which indicates that thermal decomposition requires high energy consumption. Under long thermal stability condition they were stable up to 50 °C; however, they were totally decomposed after 24 h at 100 °C. At 20–40 °C they can take days (t1/2 = 18–72 days) to years (t1/2 = 13–35 years) to be decomposed. On the other hand, oxidative decomposition in water with or without H2O2 (4–12 min and 2–5 h, respectively) was faster, resulting in decomposition of the IL-APIs in minutes to hours. The decomposition products from the oxidative process were characterized by mass spectrometry, which indicated that the presence of H2O2 facilitates an alternative, efficient, and faster method for decomposition of IL-APIs.