115820-15-0Relevant articles and documents
Synthesis of substituted salicylamines and dihydro-2H-1,3-benzoxazines
Anwar, Hany F.,Skatteb?l, Lars,Hansen, Trond Vidar
, p. 9997 - 10002 (2008/02/13)
Phenols were converted to their magnesium salts with the MgCl2-Et3N base system and subsequently reacted with Eschenmoser's salt, affording N,N-dimethyl substituted benzylamines in high to excellent yields. A series of mono N-substituted benzylamines were prepared in one-pot syntheses by ortho-formylation of phenols to corresponding salicylaldehydes, which in turn reacted with amines to imines. The imines were subsequently reduced to mono N-substituted benzylamines. Some of these benzylamines were further converted, without work-up, to mono N-substituted dihydro-2H-1,3-benzoxazines.
