115851-81-5

Basic information

• Product Name: 1,4,6-Heptatrien-3-one, 5-hydroxy-1,7-bis(4-hydroxyphenyl)-
• CAS NO: 115851-81-5
• Molecular Formula: C19H16O4
• Molecular Weight: 308.334
• Mol File: 115851-81-5.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 1,4,6-Heptatrien-3-one, 5-hydroxy-1,7-bis(4-hydroxyphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,4,6-Heptatrien-3-one, 5-hydroxy-1,7-bis(4-hydroxyphenyl)-(115851-81-5)
• EPA Substance Registry System: 1,4,6-Heptatrien-3-one, 5-hydroxy-1,7-bis(4-hydroxyphenyl)-(115851-81-5)

Safety Data

• Hazardous Substances Data: 115851-81-5(Hazardous Substances Data)

Upstream product

• 123-08-0 4-hydroxy-benzaldehyde 
• 123-54-6 acetylacetone 
• 30802-00-7 p-coumaroyl-coenzyme A 
• 524-14-1 S-(hydrogen malonyl)coenzyme A 

Downstream Products

• 828911-79-1 3,5-bis(4-hydroxystyryl)-1-phenylpyrazole 
• 201674-06-8 acetic acid 4-(7-(4-acetoxy-phenyl)-5-hydroxy-3-oxo-hepta-1,4,6-trienyl)phenyl ester 

Relevant articles and documents

Synthesis and in vitro Toxicity of d-Glucose and d-Fructose Conjugated Curcumin–Ruthenium Complexes

A series of carbohydrate-conjugated bis(demethoxy)curcumin (BDC) ligands were synthesized by using the Huisgen copper(I)-catalyzed cycloaddition between azido-functionalized d-glucose and d-fructose as well as propargyl-modified BDC. The unprotected sugar ligands were treated with Ru(bpy)2Cl2to form curcumin-conjugated Ru complexes of general formula Ru(bpy)2(L)Cl. The ligands as well as Ru complexes were analyzed by NMR, IR, UV/Vis, and fluorescence spectroscopy, mass spectrometry as well as by elemental analysis (EA). Incubation of L929, HepG2 and the breast cancer cell line MDA-MB-231 revealed lower cytotoxicity of all carbohydrate-conjugated ligands compared with BDC. The Ru complexes exhibited higher cytotoxicity than the parent ligands, in particular against HepG2 cells, whereas the noncancerous L929 cell line remained unaffected. Unexpectedly, the d-fructose-conjugated ligand and its corresponding Ru complex did not show any significant toxicity against MDA-MB-231 cells.

Synthesis, characterization and anticancer activity of a series of curcuminoids and their half-sandwich ruthenium(II) complexes

A series of curcuminoids (L1–L7) and their corresponding (η6-p-cymene)RuII(Cur)Cl complexes (1–7) were synthesized and characterized using 1H NMR spectroscopy, elemental analysis and high-resolution e

Significant enhancement in radical-scavenging activity of curcuminoids conferred by acetoxy substituent at the central methylene carbon

For a compound to be a radical-trapping antioxidant, the antioxidant-derived radical must be sufficiently inert to molecular oxygen as this would generate harmful chain-propagating peroxyl radicals. Curcumin has a unique structure with phenolic hydroxyl g