1158968-95-6

Basic information

• Product Name: N-methyl-N-phenyl-3-(o-tolyl)propiolamide
• Synonyms: N-methyl-N-phenyl-3-(o-tolyl)propiolamide
• CAS NO: 1158968-95-6
• Molecular Weight: 249.312
• Mol File: 1158968-95-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: N-methyl-N-phenyl-3-(o-tolyl)propiolamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-methyl-N-phenyl-3-(o-tolyl)propiolamide(1158968-95-6)
• EPA Substance Registry System: N-methyl-N-phenyl-3-(o-tolyl)propiolamide(1158968-95-6)

Safety Data

• Hazardous Substances Data: 1158968-95-6(Hazardous Substances Data)

Upstream product

• 7515-27-7 3-(2-methylphenyl)prop-2-ynoic acid 
• 100-61-8 N-methylaniline 
• 1343395-39-0 3-iodo-N-methyl-N-phenylpropiolamide 
• 16419-60-6 2-Methylphenylboronic acid 
• 15249-31-7 N-phenyl-N-methyl-2-propynamide 

Downstream Products

• 1078120-38-3 N-methyl-3-bromo-4-(o-methylphenyl)-1-azaspiro[4,5]deca-3,6,9-triene-2,8-dione 
• 1264264-31-4 (E)-N-methyl-N-phenyl-3-(phenylsulfonyl)-3-o-tolylacrylamide 
• 1158969-31-3 3-iodo-1-methyl-4-(2-methylphenyl)quinolin-2(1H)-one 

Relevant articles and documents

Copper-catalyzed difunctionalization of activated alkynes by radical oxidation-tandem cyclization/dearomatization to synthesize 3-trifluoromethyl spiro[4.5]trienones

A copper-catalyzed difunctionalizing trifluoromethylation of activated alkynes with the cheap reagent sodium trifluoromethanesulfinate (NaSO2CF3 or Langlois' reagent) has been developed incorporating a tandem cyclization/ dearomatiza

Palladium-catalyzed cross-coupling of electron-poor terminal alkynes with arylboronic acids under ligand-free and aerobic conditions

Palladium-catalyzed cross-coupling reaction of terminal alkynes with arylboronic acids has been described. In the presence of Pd(OAc)2 and Ag2O, a variety of terminal alkynes, including electron-poor terminal alkynes, smoothly underwent the reaction with numerous boronic acids to afford the corresponding internal alkynes in moderate to good yields. Moreover, this methodology was applied to the synthesis of 1H-isochromenes and diynes. It is noteworthy that the reaction proceeds under ligand-free and relative lower loading Pd conditions, and the maximal TONs (turnover numbers) of the reaction are up to 720,000.