1159102-03-0Relevant articles and documents
Targeting hypoxic tumor cell viability with carbohydrate-based carbonic anhydrase IX and XII inhibitors
Morris, Jason C.,Chiche, Johanna,Grellier, Caroline,Lopez, Marie,Bornaghi, Laurent F.,Maresca, Alfonso,Supuran, Claudiu T.,Pouysségur, Jacques,Poulsen, Sally-Ann
, p. 6905 - 6918 (2011/11/30)
Carbonic anhydrase (CA) enzymes, specifically membrane-bound isozymes CA IX and CA XII, underpin a pH-regulating system that enables hypoxic tumor cell survival and proliferation. CA IX and XII are implicated as potential targets for the development of ne