115956-04-2

Basic information

• Product Name: 7-Ethoxycarbonyl-9-(ethoxycarbonylmethyl)-9-azabicyclo[3,3,1]nonan-3-ol
• Synonyms: 7-ethoxycarbonyl-9-(ethoxycarbonylmethyl)-9-azabicyclo[3,3,1]nonan-3-ol;3-(Ethoxycarbonyl)-7-hydroxy-9-azabicyclo[3.3.1]nonane-9-acetic acid ethyl ester;9-Azabicyclo[3.3.1]Nonane-9-Acetic Acid, 3-(Ethoxycarbonyl)-7-Hydroxy-, Ethyl Ester;7-ETHOXYCARBONYL-9-(ETHOXYCARBONYLMETHYL)-9-AZABICYCLO[3,3,1]NONANE-3-OL
• CAS NO: 115956-04-2
• Molecular Formula: C15H25NO5
• Molecular Weight: 299.36
• EINECS: 200-252-3
• Mol File: 115956-04-2.mol
• Article Data: 6

Chemical Properties

• Melting Point: 330℃
• Boiling Point: 412.98 °C at 760 mmHg
• Flash Point: 203.563 °C
• Appearance: /
• Density: 1.165
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.504
• PKA: 14.60±0.40(Predicted)
• Water Solubility: INSOLUBLE
• CAS DataBase Reference: 7-Ethoxycarbonyl-9-(ethoxycarbonylmethyl)-9-azabicyclo[3,3,1]nonan-3-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 7-Ethoxycarbonyl-9-(ethoxycarbonylmethyl)-9-azabicyclo[3,3,1]nonan-3-ol(115956-04-2)
• EPA Substance Registry System: 7-Ethoxycarbonyl-9-(ethoxycarbonylmethyl)-9-azabicyclo[3,3,1]nonan-3-ol(115956-04-2)

Safety Data

• Hazard Codes: Xn:Harmful
• Statements: R22:; R40:
• Safety Statements: S36/37:; S45:
• Hazardous Substances Data: 115956-04-2(Hazardous Substances Data)

Usage

General Description

7-Ethoxycarbonyl-9-(ethoxycarbonylmethyl)-9-azabicyclo[3,3,1]nonan-3-ol is a chemical compound with a complex structure. It contains an ethoxycarbonyl group attached to the ninth carbon, as well as a larger ethoxycarbonylmethyl group attached to the same carbon. The compound also contains a 9-azabicyclo[3,3,1]nonan skeleton, which consists of a nine-membered ring with two nitrogen atoms. Additionally, it has a hydroxyl group attached to the third carbon. 7-Ethoxycarbonyl-9-(ethoxycarbonylmethyl)-9-azabicyclo[3,3,1]nonan-3-ol's unique structure suggests it may have potential applications in medicinal chemistry or organic synthesis due to its complex and diverse functionality.

InChI:InChI=1/C15H25NO5/c1-3-20-14(18)9-16-11-5-10(15(19)21-4-2)6-12(16)8-13(17)7-11/h10-13,17H,3-9H2,1-2H3

Upstream product

• 889135-51-7 7-ethoxycarbonyl-9-(ethoxycarbonyl-methyl)-9-azabicyclo[3.3.1]nonan-3-one methanesulfonate 

Downstream Products

• 115956-05-3 tetrahydropyranyl ether of 7-ethoxy-carbonyl-9-(ethoxycarbonylmethyl)-9-azabicyclo[3.3.1]nonan-3-ol 

Relevant articles and documents

Polymorphic Forms of Dolasetron Base and Processes of Preparing Dolasetron Base, Its Polymorphic Forms and Salt Thereof

The present disclosure relates to a process for the preparation of endo-hexahydro-8-(3-indolylcarbonyloxy)-2,6-methano-2H-quinolizin-3(4H)-one or Dolasetron base. It also discloses a process for the preparation of endo-hexahydro-8-(3-indolylcarbonyloxy)-2,6-methano-2H-quinolizin-3(4H)-one mesylate or Dolasetron mesylate. Further, the present disclosure relates to a process for producing Form I of Dolasetron base, and to the novel crystalline polymorphs, Form II, III, IV and V of Dolasetron base and industrial processes for producing them.

Use of certain esters of hexahydro-8-hydroxy-2,6-methano-2H-quinolozin-3(4H)-one and related compounds for treating cognitive disorders

This invention relates to the manufacture of certain esters of hexahydro-8-hydroxy-2,6-methano-2H-quinolizin-3(4H)-one and hexahydro-8-hydroxy-2,6-methano-2H-quinolizines and their use as medicaments in the treatment of cognitive disorders.

Esters of hexahydro-8-hydroxy-2,6-methano-2H-quinolizin-3-(4H)-one and related compounds

The present invention is directed to a group of esters of hexahydro-8-hydroxy-2,6-methano-2H-quinolizin-3(3H)-ones and related compounds. The compounds are prepared from the appropriate carboxylic acids and alcohols by standard procedures or, where steric factors are significant, a new process which makes use of heavy metal salts of super acids can be used. The compounds involved are useful in the treatment of migraine and similar disorders and in cytotoxic drug-induced vomiting.