115966-23-9 Usage
Description
Urodilatin Human, also known as UroGUIN, is a renal natriuretic peptide that is initially isolated from human urine. It is derived from the same precursor as atrial natriuretic peptide in kidney tubular cells and is secreted luminally. This peptide plays a crucial role in regulating blood pressure and fluid balance in the body.
Uses
Used in Pharmaceutical Industry:
Urodilatin Human is used as a therapeutic agent for the treatment of heart failure and certain cardiovascular conditions. It helps in promoting the excretion of sodium and water, leading to a reduction in blood volume and, consequently, blood pressure. Its natriuretic and vasorelaxant properties make it a potential candidate for the management of hypertension and fluid retention associated with heart failure.
Additionally, Urodilatin Human may be used as a diagnostic tool for assessing renal function and detecting kidney-related disorders, given its origin in the kidney tubular cells and its role in regulating fluid balance.
Biochem/physiol Actions
Urodilatin is a natriuretic factor belongs to atrial natriuretic peptide family which along with four cardiac hormones decreases human renal carcinoma cell numbers. Urodilatin induces cGMP synthesis as well as stimulates cGMP accumulation by threefold in inner medullary collecting ducts (IMCD).
Check Digit Verification of cas no
The CAS Registry Mumber 115966-23-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,1,5,9,6 and 6 respectively; the second part has 2 digits, 2 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 115966-23:
(8*1)+(7*1)+(6*5)+(5*9)+(4*6)+(3*6)+(2*2)+(1*3)=139
139 % 10 = 9
So 115966-23-9 is a valid CAS Registry Number.
InChI:InChI=1/C145H234N52O44S3/c1-11-72(6)112-137(238)171-60-106(208)172-73(7)113(214)177-86(40-41-103(146)205)122(223)190-95(63-198)116(217)170-61-108(210)175-88(51-70(2)3)114(215)169-62-109(211)176-100(133(234)187-92(56-104(147)206)127(228)193-97(65-200)130(231)186-91(54-77-27-16-13-17-28-77)126(227)180-82(31-20-45-163-142(153)154)119(220)189-94(139(240)241)55-78-36-38-79(204)39-37-78)68-243-244-69-101(134(235)185-90(53-76-25-14-12-15-26-76)115(216)168-58-105(207)167-59-107(209)174-80(29-18-43-161-140(149)150)117(218)182-87(42-50-242-10)123(224)188-93(57-110(212)213)128(229)181-85(124(225)196-112)34-23-48-166-145(159)160)195-132(233)99(67-202)194-131(232)98(66-201)192-120(221)83(32-21-46-164-143(155)156)178-118(219)81(30-19-44-162-141(151)152)179-125(226)89(52-71(4)5)184-129(230)96(64-199)191-121(222)84(33-22-47-165-144(157)158)183-135(236)102-35-24-49-197(102)138(239)74(8)173-136(237)111(148)75(9)203/h12-17,25-28,36-39,70-75,80-102,111-112,198-204H,11,18-24,29-35,40-69,148H2,1-10H3,(H2,146,205)(H2,147,206)(H,167
