1160249-14-8

Basic information

• Product Name: 8-ethoxy-2-oxo-2H-chromene-3-carbonyl chloride
• Synonyms: 8-ethoxy-2-oxo-2H-chromene-3-carbonyl chloride;2H-1-benzopyran-3-carbonyl chloride, 8-ethoxy-2-oxo-
• CAS NO: 1160249-14-8
• Molecular Formula: C12H9ClO4
• Molecular Weight: 252.65046
• Mol File: 1160249-14-8.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 8-ethoxy-2-oxo-2H-chromene-3-carbonyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 8-ethoxy-2-oxo-2H-chromene-3-carbonyl chloride(1160249-14-8)
• EPA Substance Registry System: 8-ethoxy-2-oxo-2H-chromene-3-carbonyl chloride(1160249-14-8)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 1160249-14-8(Hazardous Substances Data)

Usage

General Description

8-ethoxy-2-oxo-2H-chromene-3-carbonyl chloride is a chemical compound with the molecular formula C12H9ClO4. It is a carbonyl chloride derivative of 2-oxo-2H-chromene-3-carboxylic acid, and the presence of an ethoxy group at the 8th position of the chromene ring. It is commonly used in the synthesis of potential pharmaceutical compounds and can also be used in organic and medicinal chemistry research. 8-ethoxy-2-oxo-2H-chromene-3-carbonyl chloride may have applications in the development of drugs and other biologically active molecules due to its unique chemical structure and reactivity. Additionally, it is important to handle and store this compound with caution due to its potential toxicity and corrosive nature.

Upstream product

• 117382-66-8 8-ethoxy-2-oxo-2H-benzopyran-3-carboxylicacid ethylester 
• 24677-78-9 2,3-dihydroxybenzaldehyde 
• 492-88-6 3-ethoxysalicylaldehyde 
• 81017-24-5 8-ethoxy-2-oxo-2H-benzopyran-3-carboxylicacid 

Relevant articles and documents

Evaluation of novel N′-(3-hydroxybenzoyl)-2-oxo-2H-chromene-3-carbohydrazide derivatives as potential HIV-1 integrase inhibitors

In an attempt to identify potential new agents that are active against HIV-1 IN, a series of novel coumarin-3-carbohydrazide derivatives were designed and synthesised. The toxicity profiles of these compounds showed that they were non-toxic to human cells and they exhibited promising anti-HIV-1 IN activities with IC50 values in nM range. Also, an accompanying molecular modeling study showed that the compounds bind to the active pocket of the enzyme.

Design, syntheses, structure - Activity relationships and docking studies of coumarin derivatives as novel selective ligands for the CB2 receptor

The CB2 receptor has been considered as an inspiring drug target for the treatment of pain and immune-related diseases. In the current manuscript, a novel series of coumarin derivatives is reported to be designed and synthesized by combining the structural features of some known ligands for the cannabinoid receptors based on the CoMFA model of the lead compounds. The compounds were evaluated to be highly selective ligands for the CB2 receptor over the CB1 receptor by calcium mobilization assays. Furthermore, SAR results Therefore, molecular docking simulations were performed to calculate the receptor-ligand interactions of our synthesized compounds binding to the CB2 receptor. The understanding of the binding modes could be advantageous for further development of selective ligands for the CB2 receptor.