1160838-90-3Relevant articles and documents
Macrocyclic design strategies for small, stable parallel β-sheet scaffolds
Freire, Felix,Gellman, Samuel H.
supporting information; experimental part, p. 7970 - 7972 (2009/12/02)
(Figure Presented) Pairs of short peptide strands can be induced to adopt an antiparallel β-sheet secondary structure in aqueous solution via a macrocyclic constraint, as illustrated by many natural and designedpeptides. We show that an analogous strategy is successful for creation of small units of parallel β-sheet secondary structure in aqueous solution. Cyclization in this case requires nonpeptide segments for N-to -N and C-to-C interstrand linkage. Surprisingly, we find that only one of these segments needs to be preorganized.
