116143-09-0

Basic information

• Product Name: (3S,5R)-1-[(4-methylphenyl)sulfonyl]-3-[(4-methylphenyl)sulfonyloxy]-5-[(4-methylphenyl)sulfonyloxymethyl]pyrrolidine
• Synonyms: (3S,5R)-1-[(4-methylphenyl)sulfonyl]-3-[(4-methylphenyl)sulfonyloxy]-5-[(4-methylphenyl)sulfonyloxymethyl]pyrrolidine
• CAS NO: 116143-09-0
• Molecular Weight: 579.716
• Mol File: 116143-09-0.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: (3S,5R)-1-[(4-methylphenyl)sulfonyl]-3-[(4-methylphenyl)sulfonyloxy]-5-[(4-methylphenyl)sulfonyloxymethyl]pyrrolidine(CAS DataBase Reference)
• NIST Chemistry Reference: (3S,5R)-1-[(4-methylphenyl)sulfonyl]-3-[(4-methylphenyl)sulfonyloxy]-5-[(4-methylphenyl)sulfonyloxymethyl]pyrrolidine(116143-09-0)
• EPA Substance Registry System: (3S,5R)-1-[(4-methylphenyl)sulfonyl]-3-[(4-methylphenyl)sulfonyloxy]-5-[(4-methylphenyl)sulfonyloxymethyl]pyrrolidine(116143-09-0)

Safety Data

• Hazardous Substances Data: 116143-09-0(Hazardous Substances Data)

Upstream product

• 142928-26-5 (2R,4S)-1-(4-tolylsulfonyl)-4-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-2-<(3,5-dimethyl-1H-pyrazol-1-yl)-carbonyl>pyrrolidine 
• 1075183-51-5 N-tosyl hydroxyproline methyl ester 
• 141621-09-2 (2R,4S)-4-(tert-Butyl-dimethyl-silanyloxy)-1-(toluene-4-sulfonyl)-pyrrolidine-2-carboxylic acid 
• 141621-10-5 (2R,4S)-1-(4-tolylsulfonyl)-4-<<(1,1-dimethylethyl)dimethylsilyl>oxy>-2-formylpyrrolidine 
• 1076206-58-0 (4S)-4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-[(4-methylphenyl)sulfonyl]-D-proline methyl ester 
• 1076206-60-4 (2R,4S)-4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-1-[(4-methylphenyl)sulfonyl]-2-pyrrolidinemethanol 
• 2584-71-6 cis-hydroxy-D-proline 
• 125109-59-3 (2R,4S)-4-hydroxy-1-tosylpyrrolidine-2-carboxylic acid 
• 116143-06-7 4-(acetyloxy)-1-<(4-methylphenyl)sulfonyl>-D-proline ethyl ester 
• 116143-07-8 Ethyl (2R,4S)-4-Hydroxy-N-tosyl-2-pyrrolidinecarboxylate 
• 116143-05-6 allo-1-(4-tolylsulfonyl)-4-<<(4-methylphenyl)sulfonyl>oxy>-D-proline ethyl ester 
• 132666-67-2 (2S,4R)-ethyl 4-hydroxypyrrolidine-2-carboxylate 
• 116143-08-9 (2R,4S)-2-(Hydroxymethyl)-4-hydroxy-1-(4-tolylsulfonyl)pyrrolidine 
• 98-59-9 p-toluenesulfonyl chloride 

Downstream Products

• 114086-15-6 (1R,4R)-2-Methyl-2,5-diazabicyclo<2.2.1>heptane dihydrobromide 
• 114086-15-6 (1S,4S)-2-Methyl-2,5-diazabicyclo<2.2.1>heptane Dihydrobromide 
• 116258-17-4 (1R,4R)-5-phenylmethyl-2,5-diazabicyclo[2.2.1] heptane dihydrobromide 
• 1076206-66-0 (1R,4R)-2-[(2,3,5-trifluorophenyl)methyl]-2,5-diazabicyclo[2.2.1]heptane 
• 1195065-23-6 (1R,4R)-2-Isopropyl-5-(toluene-4-sulfonyl)-2,5-diaza-bicyclo[2.2.1]heptane 
• 1076206-64-8 (1R,4R)-2-[(4-methylphenyl)sulfonyl]-5-[(2,3,5-trifluorophenyl)methyl]-2,5-diazabicyclo[2.2.1]heptane 
• 286946-42-7 (1R,4R)-2-[(4-methylphenyl)sulfonyl]-5-(3-pyridinylmethyl)-2,5-diazabicyclo[2.2.1]heptane 
• 118354-72-6 (1R,4R)-2-(4-tolylsulfonyl)-5-(phenylmethyl)-2,5-diazabicyclo<2.2.1>heptane 
• 125224-63-7 (1R,4R)-2-(4-Tolylsulfonyl)-5-methyl-2,5-diazabicyclo<2.2.1>heptane 

Relevant articles and documents

Formation and use of boron sulfonates

Boric acid reacts swiftly with p-toluenesulfonyl chloride in pyridine-d5 to form the unstable boron sulfonate which is observed by NMR. The utility of this reaction is discussed.

ALPHA-UNSUBSTITUTED ARYLMETHYL PIPERAZINE PYRAZOLO[1,5-A] PYRIMIDINE AMIDE DERIVATIVES

Methods of preventing, treating or delaying the onset of HIV in a subject by administering to the subject novel pharmaceutically active arylmethyl pyrazolo[1,5-α ]pyrimidine amide derivatives, or pharmaceutical compositions containing the same are described. Additionally, compounds of novel pharmaceutically active arylmethyl piperazine pyrazolo[l,5-α]pyrimidine amide derivatives and their use for the manufacture of specific medicaments are described.

Synthesis of (S,S)- and (R,R)-2-Alkyl-2,5-diazabicycloheptanes

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