116185-15-0Relevant articles and documents
Total Synthesis of (+/-)-Wikstromol
Belletire,John L.,Fry,Douglas F.
, p. 4724 - 4729 (2007/10/02)
The antineoplastic prototype lignan natural product wikstromol was synthesized in racemic form by a straightforward sequence involving, as its key transformations,oxidative coupling of a carboxylic acid dianion,generation and stereoselective oxidation of a potassium enolate,and a deprotection step.The overall yield for nine steps is 29percent.Depending on the choice of oxidants for the enolate,considerable modification in the ratio of stereoisomeric products is possible.